Table 3.

ORR in the anti-EGFR group (N = 223)

Highly sensitive digital PCR
CobasTherascreen PyroCutoff 0.1%Cutoff 1%
WTRR WTMUTRR MUTWTRR WTMUTRR MUTWTRR WTMUTRR MUTWTRR WTMUTRR MUT
KRAS (exon 2)CR942.7117.4842.7220.8942134943.2124.2
PR7637736515737
SD78978972157512
PD3610361030163313
RAS (KRAS ex 2/3/4 + NRAS ex 2/3/4)CR944.8127.1846.3224.6947.1129.9948.4122.9
PR6415671355256515
SD6324612649385433
PD2719262023232521
RAS + BRAFCR945.8126.9848.3225848.8229.6850.4223.2
PR6217631753276317
SD6126573046415136
PD2323192718281927
  • NOTE: The improvement in response prediction gained by assessing the mutation status of each gene.

  • Abbreviations: WT, wild-type tumor; MUT, mutated tumor; RR, response rate; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.