Table 2.

ONC201 synergizes with docetaxel and paclitaxel in TNBC cells with decreased sensitivity to ONC201

MDA-MB-436HCC1937
CIμmol/L ONC201CIμmol/L ONC201
nmol/L paclitaxel2.551020nmol/L paclitaxel2.551020
6.250.380.560.540.866.250.550.440.671.18
12.50.710.520.430.6812.50.530.510.71.16
250.590.420.380.41250.670.680.91.32
500.980.660.650.68501.171.051.241.69
CIμmol/L ONC201CIμmol/L ONC201
nmol/L docetaxel2.551020nmol/L docetaxel2.551020
6.250.730.390.410.636.250.450.340.440.75
12.50.580.440.380.5512.50.670.450.550.78
250.460.450.460.54250.840.680.781
500.390.790.780.83501.621.251.331.49
  • NOTE: Combination indices (CI) for MDA-MB-436 and HCC1937 cells treated with different concentrations of ONC201 and paclitaxel for 72 hours. Combination indices calculated using the Chou–Talalay method. CI > 1, antagonism; CI = 1, additive effect; CI < 1, synergy.