Table 1.

Positive hits identified in combination screen with decitabine (sequential and simultaneous treatment) or TSA (sequential treatment)

CombinationDrug nameDrug functionGFP ratio
Sequential with decitabineRonnelaInsecticide4.02
AzacitidineAnticancer, DNA methylation inhibitor3.75
OuabainAntiarrhythmic, Na+/K+ channel blocker3.42
CycloheximideAntipsoriatic, protein synthesis inhibitor3.39
ProscillaridinAntiarrhythmic, Na+/K+ channel blocker3.37
Lanatoside CAntiarrhythmic, Na+/K+ channel blocker3.33
AltrenogestaProgestin, estrus cycle suppression3.33
VorinostatAnticancer, histone deacetylase inhibitor3.31
Butylated hydroxytolueneaAntioxidant3.12
DigoxinAntiarrhythmic, Na+/K+ channel blocker3.11
BromperidolaAntipsychotic3.09
Arsenic trioxideAnticancer3.08
Terbinafine hydrochlorideaAntifungal3.05
Oxybutynin chlorideaAnticholinergic3.00
Tacrine hydrochlorideaAnticholinesterase, K+ channel blocker2.98
DigitoxinAntiarrhythmic, Na+/K+ channel blocker2.95
AmoxapineaAntidepressant2.94
Ethinyl estradiolaEstrogen2.92
Phenformin hydrochlorideaAntidiabetic2.91
Diloxanide furoateaAmoebicide2.79
AcetohexamideAntidiabetic2.72
Oxantel pamoateaAnthelmintic2.71
CyproheptadineaAntipruritic2.69
Ticlopidine hydrochlorideaAntiplatelet2.68
RolitetracyclineaAntibacterial2.67
NialamideaAntidepressant2.67
Rabeprazole sodiumaGastric acid secretion inhibitor2.64
ToltrazurilaCoccidiostat2.64
LamotrigineaAnticonvulsant2.63
PyridoxineaVitamin B6 dietary supplement2.62
BenzoxiquineaAnti-infective2.60
Simultaneous with decitabineTrientine hydrochlorideaChelating agent2.57
DecitabineAnticancer, DNA methylation inhibitor2.51
NitrofurazoneaAnti-infective2.49
NitromideaAntibacterial2.47
TriclosanaAnti-infective2.37
Etidronate disodiumaBone resorption inhibitor2.22
Netilmicin sulfateaAntibacterial2.22
Arsanilic acidaAntibacterial2.22
Levobunolol hydrochlorideaAntiglaucoma2.21
Sequential with TSADecitabineAnticancer, DNA methylation inhibitor13.27
AzacitidineAnticancer, DNA methylation inhibitor6.69
DigitoxinAntiarrhythmic, Na+/K+ channel blocker5.76
MethotrexateaAnticancer4.26
PemetrexedaAnticancer4.22
Bromocriptine mesylateaAntiparkinsonian3.13
ThiramAntifungal3.08
SorafenibaAnticancer2.97
DigoxinAntiarrhythmic, Na+/K+ channel blocker2.90
  • NOTE: Drug names, drug function, and GFP ratio are shown.

  • aDrugs without epigenetic activity in monotherapy, as published previously (31).