Table 2.

Antagonistic hits identified in combination HTS with decitabine (sequential and simultaneous) or TSA (sequential)

CombinationDrug nameDrug functionGFP ratio
Sequential with decitabineFluphenazine hydrochlorideAntipsychotic0.00
PenfluridolAntipsychotic0.00
Toremiphene citrateAnticancer0.00
HexylresorcinolAntiseptic0.00
Gentian violetAntibacterial0.00
Econazole nitrateAntifungal0.01
Tamoxifen citrateAnticancer0.01
Thioridazine hydrochlorideAntipsychotic0.01
SelamectinAnthelmintic0.02
Sertraline hydrochlorideAntidepressant0.02
Perhexiline maleateCoronary vasodilator0.02
Gramicidin AAntibacterial0.02
MefloquineAntimalarial0.04
DioxybenzoneSunscreen0.04
Estradiol valerateEstrogen0.05
Simultaneous with decitabineMethylbenzethonium chlorideAnti-infective0.00
ValrubicinAnticancer0.00
Benzethonium chlorideAntiseptic0.00
Gentian violetAntibacterial0.00
DactinomycinAnticancer0.00
Epirubicin hydrochlorideAnticancer0.01
MitomycinAnticancer0.01
Nitrogen mustardAnticancer0.01
NilotinibAnticancer0.02
Gemcitabine hydrochlorideAnticancer0.03
PlicamycinAnticancer0.03
CytarabineAnticancer0.03
Mitoxantrone hydrochlorideAnticancer0.03
RapamycinAnticancer0.03
CladribineAnticancer0.03
Sequential with TSAValrubicinAnticancer0.00
Epirubicin hydrochlorideAnticancer0.00
DactinomycinAnticancer0.00
PlicamycinAnticancer0.02
MitoxantroneAnticancer0.02
TeniposideAnticancer0.09
Penicillin V potassiumAntibacterial0.11
CycloheximideAntipsoriatic0.15
Oxymetazoline hydrochlorideNasal decongestant0.17
BortezomibAnticancer0.17
Fuchsin NAnthelmintic0.18
MechlorethamineAnticancer0.19
Nitrogen mustardAnticancer0.19
Mepenzolate bromideAnticholinergic0.20
Benzethonium chlorideAntiseptic0.23
  • NOTE: Drug names, drug function, and GFP ratio are shown. Only top hits are shown in this table. A complete list of antagonistic drugs is shown in Supplementary Tables S3–S5.