Table 1A.

Associations between HSP90 expression and clinicopathologic factors in IHCC

HSP90HSP90
NegativePositiveNegativePositive
IHCC characteristics(n = 98)(n = 79)PIHCC characteristics(n = 98)(n = 79)P
Median age (range)64.0 (35–84)66.0 (41–84)0.171Perineural invasion0.525
Sex0.384 Negative4638
 Male6449 Positive5141
 Female3430Intrahepatic metastasis0.008a
Preoperative CEA level0.381 Negative7950
 ≤5.0 U/mL7558 Positive1929
 >5.0 U/mL2321Bile duct margin0.063
Preoperative CA19-9 level0.159 Negative6946
 ≤37 U/mL3824 Positive2933
 >37 U/mL5954UICC pathologic tumor status0.013a
Average tumor size0.826 T1101
 cm (range)5.1 (0.5–15.0)5.2 (1.4–15.0) T24138
Macroscopic type<0.001a T3815
 Non–mass forming243 T43925
 Mass forming7476Lymph node metastasis0.032a
Histologic classification (differentiated)0.002a Negative7045
 Mucinous and well289 Positive2834
 Moderately6966UICC pathologic stage status0.007a
 Poorly04 I101
Portal vein invasion0.482 II3020
 Negative2519 III412
 Positive7360 IVA + IVB5446
Hepatic vein invasion0.248c-MET0.304
 Negative5741 Negative4344
 Positive4138 Positive85
Lymphatic invasion0.055EGFR0.308
 Negative6643 Negative4031
 Positive3236 Positive1314
Venous invasion0.471VEGF0.232
 Negative5543 Negative2517
 Positive4336 Positive2828

NOTE: HSP90 in IHCC showed a significant association with macroscopic type (P < 0.001), histologic classification (P = 0.002), intrahepatic metastasis (P = 0.008), pathologic tumor status (P = 0.013), lymph node metastasis (P = 0.032), and pathologic stage (P = 0.007).

  • aSignificantly different (P < 0.05).