Table 2.

The in vitro cytotoxic activity of M9346A conjugates with various linker/maytansinoid combinations

IC50, nmol/L (continuous exposure)
CellsSPP-DM1SPDB-DM4Sulfo-SPDB-DM4SMCC-DM1
KB0.11 ± 0.040.08 ± 0.010.15 ± 0.080.08 ± 0.01
Igrov-10.14 ± 0.050.07 ± 0.021.0 ± 0.42.0 ± 0.7
Jeg-30.13 ± 0.080.11 ± 0.080.2 ± 0.17.0 ± 2.0

NOTE: Data represent the mean ± SD of three independent experiments.