Table 1.

Similarities across Top1 inhibitors and Top2 inhibitors and dissimilarities between Top1 and Top2 inhibitors

Camptothecin1
LMP7760.911
LMP4000.800.921
Etoposide−0.37−0.15−0.051
Doxorubicin−0.160.060.180.731
ICRF-193−0.48−0.26−0.190.760.541
Paclitaxel0.020.020.02−0.004−0.190.021
CamptothecinLMP776LMP400EtoposideDoxorubicinICRF-193Paclitaxel

NOTE: Pearson correlation coefficients were computed for all tested topoisomerase inhibitors across the DT40 DNA repair mutant panel as shown in Fig. 1. For n = 50, a Pearson coefficient of less than 0.451 corresponds to a significance probability of less than 0.001 (two-tailed test). Paclitaxel is shown as negative control (see Supplementary Fig. S4).