Table 1.

Characteristics of the top 10 upregulated tyrosine phosphorylation sites found common to both docetaxel-resistant prostate cancer models, PC3/PC3-Rx and DU145/DU145-Rx

PositionGene nameDU145-Rx SILAC RatioPC3-Rx SILAC RatioPeptide sequenceTargeted Strategy
246ACTN11.683.51_AIMTYVSSFY(ph)HAFSGAQK_
61VIM1.272.22_SLYASSPGGVY(ph)ATR_Withaferin-A
702AXL;UFO1.292.03_IYNGDY(ph)YR_R428, XL-880
359HIPK3;DYRK61.381.95_TVCSTY(ph)LQSR_
53VIM1.341.91_SLY(ph)ASSPGGVYATR_Withaferin-A
397FAK1.871.65_THAVSVSETDDY(ph)AEIIDEEDTYTMPSTR_PF-00562271, PF-04554878, Y11, Y15, GSK-2256098, TAE-226, PND-1186
577FAK1.791.51_YMEDSTYY(ph)K_PF-00562271, PF-04554878, GSK-2256098, TAE-226, PND-1186
576FAK1.761.42_YMEDSTY(ph)YK_PF-00562271, PF-04554878, GSK-2256098, TAE-226, PND-1186
815ADAM91.331.72_VSSQGNLIPARPAPAPPLY(ph)SSLT_ProA9
251PDLIM51.631.67_YTEFY(ph)HVPTHSDASK_