Table 1.

IC50 values for MET autophosphorylation (Tyr1234/1235) in eight studied MET-mutated variants

MET-mutated variantM1268TY1248HH1112YL1213VH1112LV1110IV1206LV1238I
IC50 (nmol/L)17.3>10006.9270.12.242.6224.026.1

NOTE: The values are based on least-squares fits shown in Fig. 1C.