Table 3.

Largest studies reporting lung cancers harboring EGFR exon 20 insertions

% total% of EGFR mutant
StudyYear(EGFR ex20/total)(EGFR ex20/total)Reported mutationsCosmic database nomenclature
Huang and colleagues20042% (2/101)5.1% (2/39)D761_E762insEAFQ(1)D763_E764insFQEA
S768_D770dup(1)D770_N771insSVD
Kosaka and colleagues20041.4% (4/277)3.6% (4/111)Diagrambp.A761_Y762insEAFQ?
p.A767_S768insTLA
p.V769_D770insASV
p.D770>GY
Shigematsu and colleagues20051.9% (12/617)8.9% (12/134)ASV770-772ins (4)p.V769_D770insASV
H774ins (2)p.V773_C774insH
G771ins (1)p.D770_N771insG
CV770-771ins (1)p.V769_D770insC
NP773-774ins, H775Y(1)p.P772_H773insNP
PH774-775ins(1)p.H773_V774insPH
NPH774-776ins(1)p.H773_V774insNPH
HV775-776ins(1)p.V774_C775insHV
Mitsudomi and colleagues20050% (0/59)0% (0/33)
Chou and colleagues20050% (0/54)0% (0/33)
Sasaki and colleaguesa20072.1 (7/322)13% (7/54)774_776insNPH(2)p.H773_V774insNPH
770_772insASV(1)p.V769_D770insASV
771_773insSVD(1)p.D770_N771insSVD
772_773insV(1)p.P772_H773insV
772_773insV(1)p.P772_H773insN
Sequist and colleagues20071.8% (5/278)7% (5/68)D770_N771 ins SVD(1)D770_N771 ins SVD
D770 del ins GI(1)D770>GI
N771 del ins TH(1)N771>TH
P772_H773 dup(1)H773_V774insPH
H773_V774 dup(1)V774_C775insHV
Wu and colleaguesa20082.5% (13/515)5% (13/253)S768_D770dupSVD(3)D770_N771insSVD
A767_V769dupASV(3)p.V769_D770insASV
D770_N771insD 1(1)p.D770_N771insD
P772_H773insYNP, H773Yp.P772_H773insYNP + H773Y
N771_H773dupNPH(2)p.H773_V774insNPH
D770_N771insG 2p.D770_N771insG
  • aStudies specifically dedicated to exon 20 insertions.

  • bMutations diagrammed but specific sequence not reported.