Table 2.

Clinical characteristics of patients with EGFR exon 20 insertions and comparison to all other patients and to patients with other EGFR mutations

EGFR exon 20 insertions (n = 33)No EGFR exon 20 ins (n = 1368)Other EGFR mutations (n = 291)a
Gender (female/male)22/11867/501212/79
Median age (range)66 (38–85)66 (20–96)66 (32–90)
Smoking status (never/former or current)16/17b347/1,021b138/153
Stage
 I–II/III–IV18/15629/739121/170
 I/II–IV17/16521/847106/185
Ethnicity
 Asian/Caucasian4/2874/1,27232/249
 Other12210
  • aPatients with classic sensitizing EGFR mutations only (EGFR exon 19 deletions, L858R, L861Q, and G719 mutations). EGFR T790M mutations associated with clinical resistance are excluded.

  • bP = 0.0045 (no other comparisons were statistically significant).