Table 1.

Variant codons occurring in ≥10 clade A cell lines at frequencies of ≥0.5

GeneAmino acid positionCodonVariant occurrenceRatio clade A: total cell lines
No. clade A cell linesTotal no. cell lines
AKT1242GAG35351.00
AURKA31TTT16161.00
AURKA57ATT10101.00
AURKB295TCC20201.00
BAD96CGC18181.00
BIRC5152GAG40420.95
BUB1B349CAA17171.00
BUB1B388GCG17171.00
CDKN1A31AGC12121.00
CENPE81ACT12121.00
CENPE338GTA12121.00
CENPE675CAG24241.00
CENPE1,535TTT11111.00
CENPE1,911AGC11111.00
CENPE2,090ACG10101.00
CHFR254CCA19191.00
CHFR528TTG20201.00
CHFR539GTG14141.00
FOXO3A53GCC19200.95
FRAP1479GAT64641.00
FRAP1999AAC65651.00
FRAP11,577GCG61611.00
FRAP11,851AGC27271.00
FRAP12,303CTG25251.00
INCENP36GAG27271.00
INCENP120GTT28281.00
INCENP506ATG19191.00
MAP2K264GTC10101.00
MAP2K2151GAC27271.00
MAP2K2220ATA51520.98
PIK3CA1,047CAT9150.60
PIK3CD936TAC21211.00
PIK3CG327GAT11111.00
PIK3CG442TCC18181.00
PIK3CG675AGC35351.00
PIK3R173TAC35351.00
PIK3R1326ATG24241.00
PIK3R2313CCC10101.00
PIK3R2637AGT45451.00
RPS6KB2269TTC54541.00
RPS6KB2420GCC58581.00
TSC1322ATG20201.00
TSC1445GAA21211.00
TSC2860TTT10101.00
TSC21,667GAT33331.00
TSC21,732TCG12121.00