Table 1.

Classes of MTIs

Compound classApproved agentsCompounds in developmentEffect(s) on microtubules
TaxanesPaclitaxelDJ-927Polymerization and or stabilization
Docetaxel
Albumin-bound paclitaxel
EpothilonesIxabepiloneKOS-1584
Epothilone B
Vinca alkaloidsVinblastineDepolymerization and or destabilization
Vincristine
Vinorelbine
Halichondrin bErubilin mesylate