Table 1.

Proteins affecting epigenetic modifications are deregulated in cancer

Epigenetic protein categoryEpigenetic proteinsDeregulation in cancerTumorReference
DNMTsDNMT1Mutation/overexpressionColon/multiple12, 14, 107
DNMT3AOverexpressionMultiple
DNMT3BOverexpressionMultiple
Methyl CpG Binding ProteinsMeCP2Overexpression, mutationMultiple12, 108
MBD1Overexpression, mutationMultiple
MBD2Overexpression, mutationMultiple
MBD3Overexpression, mutationMultiple
MBD4MutationColon, stomach, endometrium
HATSP300Mutations, translocations, deletionsMultiple12, 14, 39, 40
CBPMutations, translocations, deletionsMultiple
pCAFMutationsColon
MOZTranslocationsHematologic,
MORFTranslocationsHematologic Uterine Leiomyomata
Tip60UnderexpressionMultiple
HDACsHDAC1Overexpression/underexpressionMultiple/colon12, 14, 49, 76, 109, 110
HDAC2Overexpression/mutationMultiple/colon, gastric, endometrial
HDAC3OverexpressionColon
HDAC4Overexpression/underexpression/mutationProstate, breast/colon/breast
HDAC5UnderexpressionColon, AML
HDAC6OverexpressionBreast, AML
HDAC7OverexpressionColon
HDAC8OverexpressionColon
SIRT1Overexpression/underexpressionMultiple/colon
SIRT2Underexpression, deletionGlioma
SIRT3OverexpressionBreast
SIRT4UnderexpressionAML
SIRT7OverexpressionBreast, thyroid carcinoma
HMTs and PcG ProteinsMLL1Translocation, amplificationHematologic12, 14, 111, 112
MLL2AmplificationGlioma, pancreas
MLL3Mutation/deletionHematologic/colon
MLL4AmplificationSolid tumors
NSD1TranslocationAML
NSD2TranslocationMultiple myeloma
NSD3Translocation/amplificationAML/breast
EZH2Amplification, overexpressionMultiple
BLIMP1MutationsB cell lymphomas
RIZ1Underexpression, mutationsMultiple
EVI1Chromosomal rearrangementsMyeloid leukemia
PFM9DeletionCML
MEL1TranslocationHematologic
SUV39H1Mutation/overexpressionOvarian/colon
ZMYND1OverexpressionMultiple
HCP1UnderexpressionBreast
LBP1OverexpressionGastric
BMI1OverexpressionMultiple
SUZ12OverexpressionMultiple
CBX7UnderexpressionThyroid carcinoma
Histone DemethylaseGASC1AmplificationSquamous cell carcinoma14
PUT1OverexpressionBreast