Table 1.

Fusion oncogenes detected in nonsarcoma solid tumors

Nonsarcoma Solid TumorsFusion Oncogenes
Aggressive midline carcinomaBRD4-NUT, BRD3-NUT
AstrocytomaKIAA1549-BRAF, FIG/GOPC-ROS1
Secretory breast carcinomaETV6-NTRK3
Breast cancer*BCAS4-BCAS3, TBL1XR1-RGS17, ODZ4-NRG1
Kidney carcinomaMALAT1-TFEB, ASPSCR1-TFE3, PRCC-TFE3,CLTC-TFE3, NONO-TFE3, SFPQ-TFE3
Mesoblastic nephromaETV6-NTRK3
Lung adenocarcinomaEML4-ALK
Melanoma of soft parts‡EWSR1-ATF1
Meningioma‡MN1-ETV6
Salivary gland:
 pleomorphic adenomaCTNNB1-PLAG1, LIFR-PLAG1, TCEA1-PLAG1, FGFR1-PLAG1, CHCHD7-PLAG1, HMGA2-FHIT, HMGA2-NFIB
 mucoepidermoid cancerCRTC1-MAML2, CRCT3-MAML2 EWSR1-POUF5F1
Prostate carcinomaTMPRSS2-ERG, TMPRSS2-ETV1, TMPRSS2-ETV4, TMPRSS2-ETV5, HNRNPA2B1-ETV1, HERV-K-ETV1, C15ORF21-ETV1,SLC45A3-ETV1, SLC45A3-ETV5, SLC45A3-ELK4
Thyroid carcinomaRET-PTC1/CCDC6, RET-PTC2/PRKAR1A, RET-PTC3,4/NCOA4, RET-PTC5/GOLGA5, RETPTC6/TRIM24, RET-PTC7/TRIM33, RET-PTC8/KTN1, RET-PTC9/RFG9, RET-PCM1, TFG-NTRK1, TPM3-NTRK1, TPR-NTRK1 RET-D10S170, ELKS-RET, HOOKS3-Ret, RFP-RET, AKAP9-BRAF, PAX8-PPARG
  • *Detected in breast cancer cell lines.

  • Often pediatric cases.

  • Tumors exhibit mixed sarcomatous features.