Table 1.

CI values for fixed mixtures of paclitaxel and NSC 95397 in the presence or absence of dexamethasone

Paclitaxel/NSC 95397 ratio
1:500
1:250
No dexamethasone1 μmol/L dexamethasoneNo dexamethasone1 μmol/L dexamethasone
Effect level*
ED503.47 ± 1.701.08 ± 0.182.15 ± 0.441.07 ± 0.24
ED702.27 ± 0.190.88 ± 0.191.54 ± 0.210.96 ± 0.21
ED901.21 ± 0.480.64 ± 0.190.97 ± 0.110.81 ± 0.18
  • * As determined by 4-day growth inhibition assay in MDA-MB-231 cells.

  • Average ± SE combination indices of three independent experiments.