Table 1.

Effects of RPI-1 on the growth of primary s.c. tumor and spontaneous lung metastases of the NSCLC H460 xenograft

Dose (mg/kg)*TWI (%)Metastases
Incidence (%)§Mean ± SEInhibition (%)
Solvent10032 ± 8
10009014 ± 3.657**
150311008 ± 1.675††
  • Abbreviation: TWI, tumor weight inhibition.

  • * Treatments were delivered orally b.i.d. for 45 days. Solvent: polisorbate 80/ethanol/distilled water (20:8:72).

  • Tumor weight inhibition percentage in treated over control mice at day 45.

  • Observation time: day 45.

  • § Percentage of mice with metastases on total number of mice (9 mice in the solvent-treated group; 11 and 9 mice in the groups receiving 100 and 150 mg/kg RPI-1, respectively).

  • Mean number of metastatic nodules macroscopically counted in each lung.

  • Percentage of inhibition in treated over control mice.

  • ** P < 0.05 versus controls, by Mann-Whitney test.

  • †† P < 0.001 versus controls, by Mann-Whitney test.