Table 1.

Tissue concentrations of radioactivity following single and multiple oral doses (50 mg/kg) of [14C]-gefitinib to female nude mice bearing subcutaneous LoVo tumor xenografts

Single dose
Multiple dose
2 h8 h2 h8 h
Plasma5.7 ± 0.62.0 ± 0.35.1 ± 0.81.8 ± 0.2
Tumor13.8 ± 0.913.1 ± 0.916.1 ± 1.814.0 ± 1.1
Skin12.4 ± 3.57.5*10.4 ± 1.48.1*
Lung48.3*19.4 ± 4.048.9 ± 0.938.6 ± 3.7
Kidney39.2 ± 2.623.3 ± 2.054.4 ± 3.739.5 ± 2.7
Liver90 ± 1574 ± 7163 ± 26147 ± 7
  • NOTE: Results show the concentration of radioactivity (μg equivalents/g tissue) as the mean ± SE from groups of three mice, except where noted (*) when only two samples were obtained. The multiple dose groups received gefitinib as four daily oral doses.