Table 2.

Maximal induction of caspase-3 activity is achieved by inhibition of both Akt1 and Akt2

Cell lineCotreatmentFold caspase induction over cotreatment alone
Akti-1Akti-2Akti-1 + Akti-2Akti-1/2LY294002
A2780Doxorubicin3.72.8106.95
MDA-MB468Camptothecin1.51.12.22.42
BT474None1.81.23.53nd