Table 1.

Summary of ATM-dependent and -independent responses to Topo poisons

Topo PoisonResponsesATM Dependence
AdriamycinG1 checkpoint:
↑ p53(Ser20)-p (high doses only)Yes
↑ p53Yes (low doses only)
↑ p21Yes (low doses only)
↓ pRb-pYes
G2 checkpoint:
↑ CDC2(T14/Y15)-p (low doses only)No
↓ cyclin B1 (high doses only)No
↓ histone H3(S10)-pNo
CamptothecinIntra-S checkpoint:
↑ p53No
↑ CDK2(T1/Y15)-pYes (partial)
↓ BrdUrd incorporationYes (partial)