Table 3.

ITC-induced growth inhibition of cancer cells overexpressing MRP-1 or Pgp-1

Note: Used the same protocol as described in Table 1.

Cell Line
IC50m)
3 h ITC + 69 h ITC-Free
72 h ITC
AITCBITCPEITCSFAITCBITCPEITCSF
HL60/AR5.2 ± 0.94.1 ± 0.46.7 ± 0.922.6 ± 3.93.1 ± 0.23.0 ± 0.64.9 ± 0.44.3 ± 0.5
8226/Dox406.3 ± 0.52.8 ± 0.28.4 ± 0.732.3 ± 0.53.5 ± 0.32.5 ± 0.24.6 ± 0.32.3 ± 0.3