Table 1

Locoregional invasion of SCC-1 tumors in the orthotopic floor-of-mouth model

TherapyaMedian tumor volume (mm3)Median body weight (g)Muscle invasionVascular invasionBone invasionPerineural invasion
Control220256/8b5/85/83/8
C22515233/8c1/8d1/8d0/8d
  • a Therapy began on day 10 when median tumor size was 19 mm3. PBS (control) or C225 (0.8 mg) was injected i.p. biweekly for 4 weeks. Tumor weight and invasion incidence were evaluated at necropsy (day 50).

  • b Number of mice with invasion per number of injected mice.

  • c P = 0.13.

  • d P < 0.05.