Table 1

Antiproliferative effects of PPARγ ligands in vitroa

LigandCell Line
TroglitazoneBladder [39], breast [19, 20], colon [8, 9], lung [78], hematopoetic system [79], pancreas [36], prostate [24, 25], stomach [80]
RosiglitazoneColon [8, 9], prostate [24, 25, 81]
PioglitazoneBreast [19], colon [8], liposarcoma [82], hematopoetic system [79], stomach [80]
CiglitazoneLung [31], prostate [26]
GW 1929Neuroblastoma [83]
15d-PGJ2bBreast [84], colon [8], lung [31, 78], prostate [24, 25, 26], neuroblastoma [83]
  • a Growth inhibitory effects of PPARγ ligands in cancer cell lines, sometimes accompanied by induction of differentiation, apoptosis, and/or cell cycle arrest.

  • b 15d-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2.