Table 2

Effect of SU5416 on VEGF- or MCP-1-induced chemotaxis of human monocytesa

CytokineSU5416 (μm)Migrated cellRelative activity (%)b
None067.8 ± 3.74
VEGF0127 ± 14.2100
VEGF0.5106 ± 19.664.3
VEGF576.2 ± 3.7414.2c
MCP-10327 ± 16.6100
MCP-15283 ± 37.483.2
  • a Mean number of triplicate dishes ± SD. In this assay, either VEGF at 20 ng/ml or MCP-1 at 100 ng/ml was used.

  • b VEGF- or MCP-1-induced chemotactic activity was presented as 100% when cell number (67.8 ± 3.74) in the absence of cytokine was subtracted from that in the presence of each cytokine alone.

  • c Significant difference (P < 0.01) between growth factor alone and growth factor plus SU5416.