Table 1

The effect of SU5416 on cell migration of vascular endothelial cells by VEGF or PlGFa

Growth factorsSU5416 (μm)Migrated cellRelative activity (%)b
None0212 ± 23.5
VEGF0444 ± 58.3100
VEGF0.5319 ± 23.846
VEGF5253 ± 19.818c
PlGF0338 ± 38.0100
PlGF0.5273 ± 15.348
PlGF5234 ± 20.618c
  • a Mean number of triplicate dishes ± SD. In this assay, VEGF at 20 ng/ml or PlGF at 50 ng/ml was used.

  • b VEGF- or PlGF-induced chemotactic activity was presented as 100% when cell number (212 ± 23.5) in the absence of growth factor was subtracted from that in the presence of each growth factor alone.

  • c Significant difference (P < 0.01) between growth factor alone and growth factor plus SU5416.