Spotlight on Clinical Response:

BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors

Udai Banerji, Annette Affolter, Ian Judson, Richard Marais, and Paul Workman
Mol Cancer Ther 2008 7: 737-739Published Online First March 28, 2008. doi: 10.1158/1535-7163.MCT-08-0145 [Abstract] [Full Text] [PDF]  

Review:

Histone tail modifications and noncanonical functions of histones: perspectives in cancer epigenetics

Annamaria Hadnagy, Raymond Beaulieu, and Danuta Balicki
Mol Cancer Ther 2008 7: 740-748 doi: 10.1158/1535-7163.MCT-07-2284 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-B, p53, bax, and p27 levels

Catherine A. Tucker, Anita I. Kapanen, Ghania Chikh, Brad G. Hoffman, Alastair H. Kyle, Ian M. Wilson, Dana Masin, Randy D. Gascoyne, Marcel Bally, and Richard J. Klasa
Mol Cancer Ther 2008 7: 749-758Published Online First March 28, 2008. doi: 10.1158/1535-7163.MCT-07-0302 [Abstract] [Full Text] [PDF]  

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

Marielle Fournel, Claire Bonfils, Yu Hou, Pu Theresa Yan, Marie-Claude Trachy-Bourget, Ann Kalita, Jianhong Liu, Ai-Hua Lu, Nancy Z. Zhou, Marie-France Robert, Jeffrey Gillespie, James J. Wang, Hélène Ste-Croix, Jubrail Rahil, Sylvain Lefebvre, Oscar Moradei, Daniel Delorme, A. Robert MacLeod, Jeffrey M. Besterman, and Zuomei Li
Mol Cancer Ther 2008 7: 759-768 doi: 10.1158/1535-7163.MCT-07-2026 [Abstract] [Full Text] [PDF]  

Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia

C. James Chou, Michelle E. Farkas, Sherry M. Tsai, David Alvarez, Peter B. Dervan, and Joel M. Gottesfeld
Mol Cancer Ther 2008 7: 769-778 doi: 10.1158/1535-7163.MCT-08-0130 [Abstract] [Full Text] [PDF]  

Histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models

Yasushi Sasaki, Hideaki Negishi, Masashi Idogawa, Hiromu Suzuki, Hiroaki Mita, Minoru Toyota, Yasuhisa Shinomura, Kohzoh Imai, and Takashi Tokino
Mol Cancer Ther 2008 7: 779-787 doi: 10.1158/1535-7163.MCT-07-0395 [Abstract] [Full Text] [PDF]  

Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma

Nathan R. Miselis, Zhijin J. Wu, Nico Van Rooijen, and Agnes B. Kane
Mol Cancer Ther 2008 7: 788-799Published Online First March 28, 2008. doi: 10.1158/1535-7163.MCT-07-0579 [Abstract] [Full Text] [PDF]  

Sensitizing estrogen receptor–negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor

Shu-Chuan Weng, Yoko Kashida, Samuel K. Kulp, Dasheng Wang, Robert W. Brueggemeier, Charles L. Shapiro, and Ching-Shih Chen
Mol Cancer Ther 2008 7: 800-808 doi: 10.1158/1535-7163.MCT-07-0434 [Abstract] [Full Text] [PDF]  

2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition

Diansheng Zhong, Xiuju Liu, Katherine Schafer-Hales, Adam I. Marcus, Fadlo R. Khuri, Shi-Yong Sun, and Wei Zhou
Mol Cancer Ther 2008 7: 809-817 doi: 10.1158/1535-7163.MCT-07-0559 [Abstract] [Full Text] [PDF]  

Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy

Cathy Zhang, Karen Lundgren, Zhengming Yan, Maria E. Arango, Sharon Price, Andrea Huber, Joseph Higgins, Gabriel Troche, Judith Skaptason, Tatiana Koudriakova, Jim Nonomiya, Michelle Yang, Patrick O'Connor, Steve Bender, Gerrit Los, Cristina Lewis, and Bart Jessen
Mol Cancer Ther 2008 7: 818-828 doi: 10.1158/1535-7163.MCT-07-0440 [Abstract] [Full Text] [PDF]  

LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

Davide Melisi, Satoshi Ishiyama, Guido M. Sclabas, Jason B. Fleming, Qianghua Xia, Giampaolo Tortora, James L. Abbruzzese, and Paul J. Chiao
Mol Cancer Ther 2008 7: 829-840 doi: 10.1158/1535-7163.MCT-07-0337 [Abstract] [Full Text] [PDF]  

Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma

Jack S. Chen, Linda J. Zhou, Michal Entin-Meer, Xiaodong Yang, Mila Donker, Zachary A. Knight, William Weiss, Kevan M. Shokat, Daphne Haas-Kogan, and David Stokoe
Mol Cancer Ther 2008 7: 841-850 doi: 10.1158/1535-7163.MCT-07-0393 [Abstract] [Full Text] [PDF]  

Enhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature

Lin Cao, Pan Du, Shu-Han Jiang, Guang-Hui Jin, Qi-Lai Huang, and Zi-Chun Hua
Mol Cancer Ther 2008 7: 851-861 doi: 10.1158/1535-7163.MCT-07-0533 [Abstract] [Full Text] [PDF]  

Antitumor activity of fibroblast growth factor receptor 3–specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis

Jorge L. Martínez-Torrecuadrada, Lawrence H. Cheung, Paula López-Serra, Rodrigo Barderas, Marta Cañamero, Sergio Ferreiro, Michael G. Rosenblum, and J. Ignacio Casal
Mol Cancer Ther 2008 7: 862-873 doi: 10.1158/1535-7163.MCT-07-0394 [Abstract] [Full Text] [PDF]  

The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor

Nadia Godin-Heymann, Lindsey Ulkus, Brian W. Brannigan, Ultan McDermott, Jennifer Lamb, Shyamala Maheswaran, Jeffrey Settleman, and Daniel A. Haber
Mol Cancer Ther 2008 7: 874-879 doi: 10.1158/1535-7163.MCT-07-2387 [Abstract] [Full Text] [PDF]  

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex–interactive agents

Daekyu Sun, Wei-Jun Liu, Kexiao Guo, Jadrian J. Rusche, Scot Ebbinghaus, Vijay Gokhale, and Laurence H. Hurley
Mol Cancer Ther 2008 7: 880-889 doi: 10.1158/1535-7163.MCT-07-2119 [Abstract] [Full Text] [PDF]  

Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells

Grazia Ambrosini, Haider S. Cheema, Sharon Seelman, Allison Teed, Elliot B. Sambol, Samuel Singer, and Gary K. Schwartz
Mol Cancer Ther 2008 7: 890-896 doi: 10.1158/1535-7163.MCT-07-0518 [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 dependent and independent antitumor effects induced by celecoxib in urinary bladder cancer cells

Deepika Dhawan, Antonella Borgatti Jeffreys, Rong Zheng, Jane C. Stewart, and Deborah W. Knapp
Mol Cancer Ther 2008 7: 897-904 doi: 10.1158/1535-7163.MCT-07-0313 [Abstract] [Full Text] [PDF]  

UBE1L represses PML/RAR by targeting the PML domain for ISG15ylation

Sumit J. Shah, Steven Blumen, Ian Pitha-Rowe, Sutisak Kitareewan, Sarah J. Freemantle, Qing Feng, and Ethan Dmitrovsky
Mol Cancer Ther 2008 7: 905-914 doi: 10.1158/1535-7163.MCT-07-0515 [Abstract] [Full Text] [PDF]  

Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells

Maria Serova, Aïda Ghoul, Karim A. Benhadji, Sandrine Faivre, Christophe Le Tourneau, Esteban Cvitkovic, Francois Lokiec, Janet Lord, Steven M. Ogbourne, Fabien Calvo, and Eric Raymond
Mol Cancer Ther 2008 7: 915-922 doi: 10.1158/1535-7163.MCT-07-2060 [Abstract] [Full Text] [PDF]  

SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome

Xuefei Cao, Carlos Clavijo, Xu Li, H. Helen Lin, Yuan Chen, Hsiu-Ming Shih, and David K. Ann
Mol Cancer Ther 2008 7: 923-934 doi: 10.1158/1535-7163.MCT-07-0540 [Abstract] [Full Text] [PDF]  

Genome-wide DNA copy number predictors of lapatinib sensitivity in tumor-derived cell lines

Joel Greshock, Jie Cheng, David Rusnak, Anne Marie Martin, Richard Wooster, Tona Gilmer, Kwan Lee, Barbara L. Weber, and Tal Zaks
Mol Cancer Ther 2008 7: 935-943 doi: 10.1158/1535-7163.MCT-07-2072 [Abstract] [Full Text] [PDF]  

Molecular analysis of metaplastic breast carcinoma: high EGFR copy number via aneusomy

Judith A. Gilbert, Matthew P. Goetz, Carol A. Reynolds, James N. Ingle, Karin F. Giordano, Vera J. Suman, Hilary E. Blair, Robert B. Jenkins, Wilma L. Lingle, Monica M. Reinholz, Alex A. Adjei, and Matthew M. Ames
Mol Cancer Ther 2008 7: 944-951 doi: 10.1158/1535-7163.MCT-07-0570 [Abstract] [Full Text] [PDF]  

A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras

Yanan Yang, Marie Wislez, Nobukazu Fujimoto, Ludmila Prudkin, Julie G. Izzo, Futoshi Uno, Lin Ji, Amy E. Hanna, Robert R. Langley, Diane Liu, Faye M. Johnson, Ignacio Wistuba, and Jonathan M. Kurie
Mol Cancer Ther 2008 7: 952-960 doi: 10.1158/1535-7163.MCT-07-2045 [Abstract] [Full Text] [PDF]  

Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism

Minsub Shim and Thomas E. Eling
Mol Cancer Ther 2008 7: 961-971 doi: 10.1158/1535-7163.MCT-07-0470 [Abstract] [Full Text] [PDF]  

Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes

Ronald A. Lubet, Eva Szabo, Konstantin Christov, Ann M. Bode, Marna E. Ericson, Vernon E. Steele, M. Margaret Juliana, and Clinton J. Grubbs
Mol Cancer Ther 2008 7: 972-979Published Online First March 28, 2008. doi: 10.1158/1535-7163.MCT-07-2141 [Abstract] [Full Text] [PDF]  

WTp53 induction does not override MTp53 chemoresistance and radioresistance due to gain-of-function in lung cancer cells

Andrew R. Cuddihy, Farid Jalali, Carla Coackley, and Robert G. Bristow
Mol Cancer Ther 2008 7: 980-992 doi: 10.1158/1535-7163.MCT-07-0471 [Abstract] [Full Text] [PDF]  

Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53

Stéphane Supiot, Richard P. Hill, and Robert G. Bristow
Mol Cancer Ther 2008 7: 993-999 doi: 10.1158/1535-7163.MCT-07-0442 [Abstract] [Full Text] [PDF]  

Correction:

Article on TRPV6 in Breast Cancer

Mol Cancer Ther 2008 7: 1000 doi: 10.1158/1535-7163.MCT-7-4-COR [Full Text] [PDF]  

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