Research Articles: Therapeutics, Targets, and Development:

Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells

Peter Solár, Ján Koval, Jaromír Mikes, Ján Kleban, Zuzana Solárová, Ján Lazúr, Ingrid Hodorová, Peter Fedorocko, and Arthur J. Sytkowski
Mol Cancer Ther 2008 7: 2263-2271Published Online First August 6, 2008. doi: 10.1158/1535-7163.MCT-08-0483 [Abstract] [Full Text] [PDF]  

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib

Timothy P. Padera, Angera H. Kuo, Tohru Hoshida, Shan Liao, Jennifer Lobo, Kevin R. Kozak, Dai Fukumura, and Rakesh K. Jain
Mol Cancer Ther 2008 7: 2272-2279Published Online First August 6, 2008. doi: 10.1158/1535-7163.MCT-08-0182 [Abstract] [Full Text] [PDF] Supplementary Material  

Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1^–/–/Mdr1a/1b^–/– (triple-knockout) and wild-type mice

Serena Marchetti, Nienke A. de Vries, Tessa Buckle, Maria J. Bolijn, Maria A.J. van Eijndhoven, Jos H. Beijnen, Roberto Mazzanti, Olaf van Tellingen, and Jan H.M. Schellens
Mol Cancer Ther 2008 7: 2280-2287 doi: 10.1158/1535-7163.MCT-07-2250 [Abstract] [Full Text] [PDF]  

Improved tumor targeting of anti–epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

Bernard M. Tijink, Toon Laeremans, Marianne Budde, Marijke Stigter-van Walsum, Torsten Dreier, Hans J. de Haard, C. René Leemans, and Guus A.M.S. van Dongen
Mol Cancer Ther 2008 7: 2288-2297 doi: 10.1158/1535-7163.MCT-07-2384 [Abstract] [Full Text] [PDF]  

Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells

Hongtao Gu, Xiequn Chen, Guangxun Gao, and Hongjuan Dong
Mol Cancer Ther 2008 7: 2298-2307 doi: 10.1158/1535-7163.MCT-08-0186 [Abstract] [Full Text] [PDF] Supplementary Material  

Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth

Jacqueline Sayyah, Andrew Magis, David A. Ostrov, Robert W. Allan, Raul C. Braylan, and Peter P. Sayeski
Mol Cancer Ther 2008 7: 2308-2318 doi: 10.1158/1535-7163.MCT-08-0279 [Abstract] [Full Text] [PDF] Supplementary Material  

Elesclomol induces cancer cell apoptosis through oxidative stress

Jessica R. Kirshner, Suqin He, Vishwasenani Balasubramanyam, Jane Kepros, Chin-Yu Yang, Mei Zhang, Zhenjian Du, James Barsoum, and John Bertin
Mol Cancer Ther 2008 7: 2319-2327 doi: 10.1158/1535-7163.MCT-08-0298 [Abstract] [Full Text] [PDF] Supplementary Material  

Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms

Sharmila Shankar, Qinghe Chen, Suthakar Ganapathy, Karan P. Singh, and Rakesh K. Srivastava
Mol Cancer Ther 2008 7: 2328-2338 doi: 10.1158/1535-7163.MCT-08-0216 [Abstract] [Full Text] [PDF]  

BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis

Justin L. Mott, Steve F. Bronk, Ruben A. Mesa, Scott H. Kaufmann, and Gregory J. Gores
Mol Cancer Ther 2008 7: 2339-2347 doi: 10.1158/1535-7163.MCT-08-0285 [Abstract] [Full Text] [PDF]  

Androgen receptor inactivation contributes to antitumor efficacy of 17-hydroxylase/17,20-lyase inhibitor 3β-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer

Tadas Vasaitis, Aashvini Belosay, Adam Schayowitz, Aakanksha Khandelwal, Pankaj Chopra, Lalji K. Gediya, Zhiyong Guo, Hong-Bin Fang, Vincent C.O. Njar, and Angela M.H. Brodie
Mol Cancer Ther 2008 7: 2348-2357 doi: 10.1158/1535-7163.MCT-08-0230 [Abstract] [Full Text] [PDF]  

Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines

Magdalena Zajac, Maria Victoria Moneo, Amancio Carnero, Javier Benitez, and Beatriz Martínez-Delgado
Mol Cancer Ther 2008 7: 2358-2366 doi: 10.1158/1535-7163.MCT-08-0327 [Abstract] [Full Text] [PDF] Supplementary Material  

SN52, a novel nuclear factor-B inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation

Yong Xu, Fang Fang, Daret K. St. Clair, Pradoldej Sompol, Sajni Josson, and William H. St. Clair
Mol Cancer Ther 2008 7: 2367-2376 doi: 10.1158/1535-7163.MCT-08-0238 [Abstract] [Full Text] [PDF]  

Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer

Zhenfeng Duan, Edward J. Weinstein, Diana Ji, Rachel Y. Ames, Edwin Choy, Henry Mankin, and Francis J. Hornicek
Mol Cancer Ther 2008 7: 2377-2385Published Online First August 7, 2008. doi: 10.1158/1535-7163.MCT-08-0316 [Abstract] [Full Text] [PDF] Supplementary Material  

Jadomycin B, an Aurora-B kinase inhibitor discovered through virtual screening

Da-Hua Fu, Wei Jiang, Jian-Ting Zheng, Gui-Yu Zhao, Yan Li, Hong Yi, Zhuo-Rong Li, Jian-Dong Jiang, Ke-Qian Yang, Yanchang Wang, and Shu-Yi Si
Mol Cancer Ther 2008 7: 2386-2393 doi: 10.1158/1535-7163.MCT-08-0035 [Abstract] [Full Text] [PDF]  

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1

Alessandra Blasina, Jill Hallin, Enhong Chen, Maria Elena Arango, Eugenia Kraynov, James Register, Stephan Grant, Sacha Ninkovic, Ping Chen, Tim Nichols, Patrick O'Connor, and Kenna Anderes
Mol Cancer Ther 2008 7: 2394-2404 doi: 10.1158/1535-7163.MCT-07-2391 [Abstract] [Full Text] [PDF] Supplementary Material  

The G-rich promoter and G-rich coding sequence of basic fibroblast growth factor are the targets of thalidomide in glioma

Szu-Chieh Mei and Rong-Tsun Wu
Mol Cancer Ther 2008 7: 2405-2414Published Online First August 6, 2008. doi: 10.1158/1535-7163.MCT-07-2398 [Abstract] [Full Text] [PDF] Supplementary Material  

New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine

Stephan A. Veltkamp, Dick Pluim, Maria A.J. van Eijndhoven, Maria J. Bolijn, Felix H.G. Ong, Rajgopal Govindarajan, Jashvant D. Unadkat, Jos H. Beijnen, and Jan H.M. Schellens
Mol Cancer Ther 2008 7: 2415-2425 doi: 10.1158/1535-7163.MCT-08-0137 [Abstract] [Full Text] [PDF]  

IRC-083927 is a new tubulin binder that inhibits growth of human tumor cells resistant to standard tubulin-binding agents

Anne-Marie Liberatore, Hélène Coulomb, Dominique Pons, Olivier Dutruel, Philip G. Kasprzyk, Mark Carlson, Ann Savola Nelson, Simon P. Newman, Chloe Stengel, Pierrïck Auvray, Vincent Hesry, Béatrice Foll, Nadine Narboux, Delphine Morlais, Mélissa Le Moing, Sonia Bernetiere, Raphael Dellile, Jose Camara, Eric Ferrandis, Dennis C. Bigg, and Grégoire P. Prévost
Mol Cancer Ther 2008 7: 2426-2434 doi: 10.1158/1535-7163.MCT-08-0208 [Abstract] [Full Text] [PDF]  

Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography

L.W. Lawrence Woo, Delphine S. Fischer, Christopher M. Sharland, Melanie Trusselle, Paul A. Foster, Surinder K. Chander, Anna Di Fiore, Claudiu T. Supuran, Giuseppina De Simone, Atul Purohit, Michael J. Reed, and Barry V.L. Potter
Mol Cancer Ther 2008 7: 2435-2444 doi: 10.1158/1535-7163.MCT-08-0195 [Abstract] [Full Text] [PDF] Supplementary Material  

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2

Jirouta Kitagaki, Keli K. Agama, Yves Pommier, Yili Yang, and Allan M. Weissman
Mol Cancer Ther 2008 7: 2445-2454 doi: 10.1158/1535-7163.MCT-08-0063 [Abstract] [Full Text] [PDF]  

High-content imaging characterization of cell cycle therapeutics through in vitro and in vivo subpopulation analysis

Jonathan Low, Shuguang Huang, Wayne Blosser, Michele Dowless, John Burch, Blake Neubauer, and Louis Stancato
Mol Cancer Ther 2008 7: 2455-2463 doi: 10.1158/1535-7163.MCT-08-0328 [Abstract] [Full Text] [PDF]  

Tumor-associated CD75s- and iso-CD75s-gangliosides are potential targets for adjuvant therapy in pancreatic cancer

Ute Distler, Jamal Souady, Marcel Hülsewig, Irena Drmic-Hofman, Jörg Haier, Axel Denz, Robert Grützmann, Christian Pilarsky, Norbert Senninger, Klaus Dreisewerd, Stefan Berkenkamp, M. Alexander Schmidt, Jasna Peter-Katalinic, and Johannes Müthing
Mol Cancer Ther 2008 7: 2464-2475 doi: 10.1158/1535-7163.MCT-08-0353 [Abstract] [Full Text] [PDF] Supplementary Material  

Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma

Luigia Longo, Francesca Platini, Anna Scardino, Oscar Alabiso, Giuseppe Vasapollo, and Luciana Tessitore
Mol Cancer Ther 2008 7: 2476-2485 doi: 10.1158/1535-7163.MCT-08-0361 [Abstract] [Full Text] [PDF] Supplementary Material  

Anti-CD30 diabody-drug conjugates with potent antitumor activity

Kristine M. Kim, Charlotte F. McDonagh, Lori Westendorf, Lindsay L. Brown, Django Sussman, Tiffany Feist, Robert Lyon, Stephen C. Alley, Nicole M. Okeley, Xinqun Zhang, Melissa C. Thompson, Ivan Stone, Hans-Peter Gerber, and Paul J. Carter
Mol Cancer Ther 2008 7: 2486-2497 doi: 10.1158/1535-7163.MCT-08-0388 [Abstract] [Full Text] [PDF] Supplementary Material  

Human colorectal tumors and metastases express Gb₃ and can be targeted by an intestinal pathogen-based delivery tool

Thomas Falguières, Matthias Maak, Claus von Weyhern, Marianne Sarr, Xavier Sastre, Marie-France Poupon, Sylvie Robine, Ludger Johannes, and Klaus-Peter Janssen
Mol Cancer Ther 2008 7: 2498-2508Published Online First August 7, 2008. doi: 10.1158/1535-7163.MCT-08-0430 [Abstract] [Full Text] [PDF] Supplementary Material  

Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN

Sarah A. Martin and Toru Ouchi
Mol Cancer Ther 2008 7: 2509-2516 doi: 10.1158/1535-7163.MCT-08-0199 [Abstract] [Full Text] [PDF]  

Optimization of antibody binding to FcRIIa enhances macrophage phagocytosis of tumor cells

John O. Richards, Sher Karki, Greg A. Lazar, Hsing Chen, Wei Dang, and John R. Desjarlais
Mol Cancer Ther 2008 7: 2517-2527 doi: 10.1158/1535-7163.MCT-08-0201 [Abstract] [Full Text] [PDF] Suplementary Material  

Adenoviral endoplasmic reticulum–targeted mda-7/interleukin-24 vector enhances human cancer cell killing

Abujiang Pataer, Wenxian Hu, Lu Xiaolin, Sunil Chada, Jack A. Roth, Kelly K. Hunt, and Stephen G. Swisher
Mol Cancer Ther 2008 7: 2528-2535 doi: 10.1158/1535-7163.MCT-08-0083 [Abstract] [Full Text] [PDF] Suplementary Material  

Human endothelial precursor cells express tumor endothelial marker 1/endosialin/CD248

Rebecca G. Bagley, Cecile Rouleau, Thia St. Martin, Paula Boutin, William Weber, Melanie Ruzek, Nakayuki Honma, Mariana Nacht, Srinivas Shankara, Shiro Kataoka, Isao Ishida, Bruce L. Roberts, and Beverly A. Teicher
Mol Cancer Ther 2008 7: 2536-2546 doi: 10.1158/1535-7163.MCT-08-0050 [Abstract] [Full Text] [PDF]  

Tumor necrosis factor-–induced accentuation in cryoinjury: mechanisms in vitro and in vivo

Jing Jiang, Raghav Goel, M. Arif Iftekhar, Rachana Visaria, John D. Belcher, Gregory M. Vercellotti, and John C. Bischof
Mol Cancer Ther 2008 7: 2547-2555 doi: 10.1158/1535-7163.MCT-07-2421 [Abstract] [Full Text] [PDF]  

Fatty acid synthase inhibition results in a magnetic resonance–detectable drop in phosphocholine

James Ross, Amer M. Najjar, Madhuri Sankaranarayanapillai, William P. Tong, Kumaralal Kaluarachchi, and Sabrina M. Ronen
Mol Cancer Ther 2008 7: 2556-2565 doi: 10.1158/1535-7163.MCT-08-0015 [Abstract] [Full Text] [PDF]  

Relaxin treatment of solid tumors: effects on electric field–mediated gene delivery

Joshua Henshaw, Brian Mossop, and Fan Yuan
Mol Cancer Ther 2008 7: 2566-2573 doi: 10.1158/1535-7163.MCT-08-0435 [Abstract] [Full Text] [PDF]  

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