Research Articles: Therapeutics, Targets, and Development:

Laser postionization secondary neutral mass spectrometry in tissue: a powerful tool for elemental and molecular imaging in the development of targeted drugs

Andrea Wittig, Heinrich F. Arlinghaus, Christian Kriegeskotte, Raymond L. Moss, Klaas Appelman, Kurt W. Schmid, and Wolfgang A.G. Sauerwein
Mol Cancer Ther 2008 7: 1763-1771 doi: 10.1158/1535-7163.MCT-08-0191 [Abstract] [Full Text] [PDF]  

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair

Mahmoud Toulany, Rainer Kehlbach, Urszula Florczak, Ali Sak, Shaomeng Wang, Jianyong Chen, Markus Lobrich, and H. Peter Rodemann
Mol Cancer Ther 2008 7: 1772-1781 doi: 10.1158/1535-7163.MCT-07-2200 [Abstract] [Full Text] [PDF]  

eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling

Alpana Soni, Argun Akcakanat, Gopal Singh, David Luyimbazi, Yuhuan Zheng, Doyil Kim, Ana Gonzalez-Angulo, and Funda Meric-Bernstam
Mol Cancer Ther 2008 7: 1782-1788 doi: 10.1158/1535-7163.MCT-07-2357 [Abstract] [Full Text] [PDF]  

Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways

Tingfang Yi, Sung-Gook Cho, Zhengfang Yi, Xiufeng Pang, Melissa Rodriguez, Ying Wang, Gautam Sethi, Bharat B. Aggarwal, and Mingyao Liu
Mol Cancer Ther 2008 7: 1789-1796 doi: 10.1158/1535-7163.MCT-08-0124 [Abstract] [Full Text] [PDF]  

Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase

Dhananjay P. Kunte, Ramesh K. Wali, Jennifer L. Koetsier, and Hemant K. Roy
Mol Cancer Ther 2008 7: 1797-1806 doi: 10.1158/1535-7163.MCT-08-0022 [Abstract] [Full Text] [PDF]  

Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma

Hui Guan, Zhichao Zhou, Gary E. Gallick, Shu-Fang Jia, Jaime Morales, Anil K. Sood, Seth J. Corey, and Eugenie S. Kleinerman
Mol Cancer Ther 2008 7: 1807-1816 doi: 10.1158/1535-7163.MCT-08-0058 [Abstract] [Full Text] [PDF]  

Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells

Manesh Chittezhath, Gagan Deep, Rana P. Singh, Chapla Agarwal, and Rajesh Agarwal
Mol Cancer Ther 2008 7: 1817-1826 doi: 10.1158/1535-7163.MCT-08-0256 [Abstract] [Full Text] [PDF]  

Active roles for inhibitory B kinases and β in nuclear factor-B–mediated chemoresistance to doxorubicin

Brian K. Bednarski, Xiaoyu Ding, Kavita Coombe, Albert S. Baldwin, and Hong J. Kim
Mol Cancer Ther 2008 7: 1827-1835 doi: 10.1158/1535-7163.MCT-08-0321 [Abstract] [Full Text] [PDF]  

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

Dimitri Pchejetski, Nicolas Doumerc, Muriel Golzio, Maria Naymark, Justin Teissié, Takafumi Kohama, Jonathan Waxman, Bernard Malavaud, and Olivier Cuvillier
Mol Cancer Ther 2008 7: 1836-1845 doi: 10.1158/1535-7163.MCT-07-2322 [Abstract] [Full Text] [PDF] Supplementary Material  

Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells

Dongwei Zhang, Ashutosh Pal, William G. Bornmann, Fumiyuki Yamasaki, Francisco J. Esteva, Gabriel N. Hortobagyi, Chandra Bartholomeusz, and Naoto T. Ueno
Mol Cancer Ther 2008 7: 1846-1850 doi: 10.1158/1535-7163.MCT-08-0168 [Abstract] [Full Text] [PDF]  

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

Sauveur-Michel Maira, Frédéric Stauffer, Josef Brueggen, Pascal Furet, Christian Schnell, Christine Fritsch, Saskia Brachmann, Patrick Chène, Alain De Pover, Kevin Schoemaker, Doriano Fabbro, Daniela Gabriel, Marjo Simonen, Leon Murphy, Peter Finan, William Sellers, and Carlos García-Echeverría
Mol Cancer Ther 2008 7: 1851-1863Published Online First July 7, 2008. doi: 10.1158/1535-7163.MCT-08-0017 [Abstract] [Full Text] [PDF] Supplementary Material  

Delivery of PTEN via a novel gene microcapsule sensitizes prostate cancer cells to irradiation

Atsushi Tomioka, Motoyoshi Tanaka, Marco A. De Velasco, Satoshi Anai, Satoshi Takada, Toshihiro Kushibiki, Yasuhiko Tabata, Charles J. Rosser, Hirotsugu Uemura, and Yoshihiko Hirao
Mol Cancer Ther 2008 7: 1864-1870 doi: 10.1158/1535-7163.MCT-07-2198 [Abstract] [Full Text] [PDF]  

A novel combination: ranpirnase and rosiglitazone induce a synergistic apoptotic effect by down-regulating Fra-1 and Survivin in cancer cells

Maria E. Ramos-Nino and Benjamin Littenberg
Mol Cancer Ther 2008 7: 1871-1879Published Online First July 7, 2008. doi: 10.1158/1535-7163.MCT-08-0308 [Abstract] [Full Text] [PDF]  

Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Andrea J. Gonzales, Kenneth E. Hook, Irene W. Althaus, Paul A. Ellis, Erin Trachet, Amy M. Delaney, Patricia J. Harvey, Teresa A. Ellis, Danielle M. Amato, James M. Nelson, David W. Fry, Tong Zhu, Cho-Ming Loi, Stephen A. Fakhoury, Kevin M. Schlosser, Karen E. Sexton, R. Thomas Winters, Jessica E. Reed, Alex J. Bridges, Daniel J. Lettiere, Deborah A. Baker, Jianxin Yang, Helen T. Lee, Haile Tecle, and Patrick W. Vincent
Mol Cancer Ther 2008 7: 1880-1889Published Online First July 7, 2008. doi: 10.1158/1535-7163.MCT-07-2232 [Abstract] [Full Text] [PDF] Supplementary Material  

Single-chain antibody/activated BID chimeric protein effectively suppresses HER2-positive tumor growth

Xiu-Chun Qiu, Yan-Ming Xu, Fang Wang, Qing-Yu Fan, Li-Feng Wang, Bao-An Ma, Lin-Tao Jia, Jing Zhao, Yan-Ling Meng, Li-Bo Yao, Si-Yi Chen, and An-Gang Yang
Mol Cancer Ther 2008 7: 1890-1899 doi: 10.1158/1535-7163.MCT-07-2235 [Abstract] [Full Text] [PDF]  

Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer

Danica L. Rowe, Tuba Ozbay, Laura M. Bender, and Rita Nahta
Mol Cancer Ther 2008 7: 1900-1908 doi: 10.1158/1535-7163.MCT-08-0012 [Abstract] [Full Text] [PDF]  

c-Jun knockdown sensitizes osteosarcoma to doxorubicin

Crispin R. Dass, Levon M. Khachigian, and Peter F.M. Choong
Mol Cancer Ther 2008 7: 1909-1912 doi: 10.1158/1535-7163.MCT-08-0086 [Abstract] [Full Text] [PDF]  

Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis

Laura P. Stabile, Mary E. Rothstein, Phouthone Keohavong, Jide Jin, Jinling Yin, Stephanie R. Land, Sanja Dacic, The Minh Luong, K. Jin Kim, Austin M. Dulak, and Jill M. Siegfried
Mol Cancer Ther 2008 7: 1913-1922 doi: 10.1158/1535-7163.MCT-07-2169 [Abstract] [Full Text] [PDF] Supplementary Material  

Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model

Akihiko Miyanaga, Akihiko Gemma, Rintaro Noro, Kiyoko Kataoka, Kuniko Matsuda, Michiya Nara, Tetsuya Okano, Masahiro Seike, Akinobu Yoshimura, Akiko Kawakami, Haruka Uesaka, Hiroki Nakae, and Shoji Kudoh
Mol Cancer Ther 2008 7: 1923-1930Published Online First July 7, 2008. doi: 10.1158/1535-7163.MCT-07-2140 [Abstract] [Full Text] [PDF] Supplementary Material  

Array-based analysis of the effects of trichostatin A and CG-1521 on cell cycle and cell death in LNCaP prostate cancer cells

Somdutta Roy, Randy Jeffrey, and Martin Tenniswood
Mol Cancer Ther 2008 7: 1931-1939 doi: 10.1158/1535-7163.MCT-07-2353 [Abstract] [Full Text] [PDF]  

Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis

Marianne Kraus, Elke Malenke, Jeannette Gogel, Holger Müller, Thomas Rückrich, Herman Overkleeft, Huib Ovaa, Ewa Koscielniak, Jörg Thomas Hartmann, and Christoph Driessen
Mol Cancer Ther 2008 7: 1940-1948 doi: 10.1158/1535-7163.MCT-07-2375 [Abstract] [Full Text] [PDF]  

Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-B and activator protein-1 related mechanisms

Zhong Chen, Justin L. Ricker, Pramit S. Malhotra, Liesl Nottingham, Lorena Bagain, Tin Lap Lee, Ning T. Yeh, and Carter Van Waes
Mol Cancer Ther 2008 7: 1949-1960 doi: 10.1158/1535-7163.MCT-07-2046 [Abstract] [Full Text] [PDF] Supplementary Material  

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

Richard Sullivan, Geneviève C. Paré, Lisa J. Frederiksen, Gregg L. Semenza, and Charles H. Graham
Mol Cancer Ther 2008 7: 1961-1973 doi: 10.1158/1535-7163.MCT-08-0198 [Abstract] [Full Text] [PDF] Supplementary Material  

Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1 and -2

Maura Puppo, Florinda Battaglia, Catherine Ottaviano, Silvana Delfino, Domenico Ribatti, Luigi Varesio, and Maria Carla Bosco
Mol Cancer Ther 2008 7: 1974-1984 doi: 10.1158/1535-7163.MCT-07-2059 [Abstract] [Full Text] [PDF]  

HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair

Thuy T. Koll, Steven S. Feis, Mollie H. Wright, Modupe M. Teniola, Mekel M. Richardson, Ana I. Robles, John Bradsher, Jacek Capala, and Lyuba Varticovski
Mol Cancer Ther 2008 7: 1985-1992 doi: 10.1158/1535-7163.MCT-07-2104 [Abstract] [Full Text] [PDF]  

S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells

Dongmei Wang, Zhenwen Zhao, Andrea Caperell-Grant, Gong Yang, Samuel C. Mok, Jinsong Liu, Robert M. Bigsby, and Yan Xu
Mol Cancer Ther 2008 7: 1993-2002 doi: 10.1158/1535-7163.MCT-08-0088 [Abstract] [Full Text] [PDF] Supplementary Material  

Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase

Tatiana Okouneva, Olga Azarenko, Leslie Wilson, Bruce A. Littlefield, and Mary Ann Jordan
Mol Cancer Ther 2008 7: 2003-2011 doi: 10.1158/1535-7163.MCT-08-0095 [Abstract] [Full Text] [PDF]  

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

Gang-Ming Zou and Anirban Maitra
Mol Cancer Ther 2008 7: 2012-2021 doi: 10.1158/1535-7163.MCT-08-0113 [Abstract] [Full Text] [PDF]  

Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

Jimmy M-M. Kwok, Stephen S. Myatt, Charles M. Marson, R. Charles Coombes, Demetra Constantinidou, and Eric W-F. Lam
Mol Cancer Ther 2008 7: 2022-2032 doi: 10.1158/1535-7163.MCT-08-0188 [Abstract] [Full Text] [PDF]  

Anti-ganglioside antibody-induced tumor cell death by loss of membrane integrity

Lourdes Roque-Navarro, Krittalak Chakrabandhu, Joel de León, Sandra Rodríguez, Carlos Toledo, Adriana Carr, Cristina Mateo de Acosta, Anne-Odile Hueber, and Rolando Pérez
Mol Cancer Ther 2008 7: 2033-2041 doi: 10.1158/1535-7163.MCT-08-0222 [Abstract] [Full Text] [PDF]  

Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis

Irina V. Lebedeva, Zhao-zhong Su, Nichollaq Vozhilla, Lejuan Chatman, Devanand Sarkar, Paul Dent, Mohammad Athar, and Paul B. Fisher
Mol Cancer Ther 2008 7: 2042-2050 doi: 10.1158/1535-7163.MCT-08-0245 [Abstract] [Full Text] [PDF]  

Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968

Claudio Pisano, Michelandrea De Cesare, Giovanni Luca Beretta, Valentina Zuco, Graziella Pratesi, Sergio Penco, Loredana Vesci, Rosanna Foderà, Fabiana Fosca Ferrara, Mario Berardino Guglielmi, Paolo Carminati, Sabrina Dallavalle, Gabriella Morini, Lucio Merlini, Augusto Orlandi, and Franco Zunino
Mol Cancer Ther 2008 7: 2051-2059 doi: 10.1158/1535-7163.MCT-08-0266 [Abstract] [Full Text] [PDF]  

Arsenic trioxide enhances the therapeutic efficacy of radiation treatment of oral squamous carcinoma while protecting bone

Pawan Kumar, Qinghong Gao, Yu Ning, Zhuo Wang, Paul H. Krebsbach, and Peter J. Polverini
Mol Cancer Ther 2008 7: 2060-2069 doi: 10.1158/1535-7163.MCT-08-0287 [Abstract] [Full Text] [PDF]  

Proteomic characterization of cytoskeletal and mitochondrial class III β-tubulin

Lucia Cicchillitti, Roberta Penci, Michela Di Michele, Flavia Filippetti, Domenico Rotilio, Maria Benedetta Donati, Giovanni Scambia, and Cristiano Ferlini
Mol Cancer Ther 2008 7: 2070-2079 doi: 10.1158/1535-7163.MCT-07-2370 [Abstract] [Full Text] [PDF] Supplementary Material  

Antiangiogenic vinflunine affects EB1 localization and microtubule targeting to adhesion sites

Stéphane Honoré, Alessandra Pagano, Géraldine Gauthier, Véronique Bourgarel-Rey, Pascal Verdier-Pinard, Karine Civiletti, Anna Kruczynski, and Diane Braguer
Mol Cancer Ther 2008 7: 2080-2089 doi: 10.1158/1535-7163.MCT-08-0156 [Abstract] [Full Text] [PDF] Suplementary Material  

Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts

Francescopaolo Di Cello, Joelle Hillion, Jeanne Kowalski, Brigitte M. Ronnett, Abimbola Aderinto, David L. Huso, and Linda M.S. Resar
Mol Cancer Ther 2008 7: 2090-2095 doi: 10.1158/1535-7163.MCT-07-2282 [Abstract] [Full Text] [PDF] Supplementary Material  

Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor--dependent and estrogen receptor--independent mechanisms

Xinghua Long, Meiyun Fan, Robert M. Bigsby, and Kenneth P. Nephew
Mol Cancer Ther 2008 7: 2096-2108 doi: 10.1158/1535-7163.MCT-07-2350 [Abstract] [Full Text] [PDF]  

5,5'-Dibromo-bis(3'-indolyl)methane induces Krüppel-like factor 4 and p21 in colon cancer cells

Sung Dae Cho, Sudhakar Chintharlapalli, Maen Abdelrahim, Sabitha Papineni, Shengxi Liu, Jingjing Guo, Ping Lei, Ala Abudayyeh, and Stephen Safe
Mol Cancer Ther 2008 7: 2109-2120 doi: 10.1158/1535-7163.MCT-07-2311 [Abstract] [Full Text] [PDF]  

Differential antiproliferative mechanisms of novel derivative of benzimidazo[1,2-]quinoline in colon cancer cells depending on their p53 status

Mirela Sedic, Miroslav Poznic, Peter Gehrig, Mike Scott, Ralph Schlapbach, Marijana Hranjec, Grace Karminski-Zamola, Kresimir Pavelic, and Sandra Kraljevic Pavelic
Mol Cancer Ther 2008 7: 2121-2132 doi: 10.1158/1535-7163.MCT-07-2261 [Abstract] [Full Text] [PDF] Supplementary Material  

Antimigratory effect of TK1-2 is mediated in part by interfering with integrin ₂β₁

Hyun-Kyung Kim, Dae-Shik Oh, Sang-Bae Lee, Jung-Min Ha, and Young Ae Joe
Mol Cancer Ther 2008 7: 2133-2141 doi: 10.1158/1535-7163.MCT-07-2405 [Abstract] [Full Text] [PDF] Supplementary Material  

Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability

Sigrid A. Rajasekaran, Jason J. Christiansen, Ingrid Schmid, Eri Oshima, Kathleen Sakamoto, Jasminder Weinstein, Nagesh P. Rao, and Ayyappan K. Rajasekaran
Mol Cancer Ther 2008 7: 2142-2151 doi: 10.1158/1535-7163.MCT-08-0005 [Abstract] [Full Text] [PDF]  

Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin

Olga Kovalchuk, Jody Filkowski, James Meservy, Yaroslav Ilnytskyy, Volodymyr P. Tryndyak, Vasyl' F. Chekhun, and Igor P. Pogribny
Mol Cancer Ther 2008 7: 2152-2159 doi: 10.1158/1535-7163.MCT-08-0021 [Abstract] [Full Text] [PDF] Supplementary Material  

RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis

Robert E. Miller, Martine Roudier, Jon Jones, Allison Armstrong, Jude Canon, and William C. Dougall
Mol Cancer Ther 2008 7: 2160-2169Published Online First July 7, 2008. doi: 10.1158/1535-7163.MCT-08-0046 [Abstract] [Full Text] [PDF]  

Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation

Jing Zhou, Guo-Dong Lu, Chye-Sun Ong, Choon-Nam Ong, and Han-Ming Shen
Mol Cancer Ther 2008 7: 2170-2180 doi: 10.1158/1535-7163.MCT-08-0071 [Abstract] [Full Text] [PDF] Supplementary Material  

Cloning and apoptosis-inducing activities of canine and feline TRAIL

Sing Rong, Jenny H. Cai, and Jennifer Andrews
Mol Cancer Ther 2008 7: 2181-2191 doi: 10.1158/1535-7163.MCT-07-2139 [Abstract] [Full Text] [PDF]  

Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa

Yang Meng, Wenhua Tang, Yao Dai, Xiaoqing Wu, Meilan Liu, Qing Ji, Min Ji, Kenneth Pienta, Theodore Lawrence, and Liang Xu
Mol Cancer Ther 2008 7: 2192-2202 doi: 10.1158/1535-7163.MCT-08-0333 [Abstract] [Full Text] [PDF] Supplementary Material  

Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor ligand-induced growth inhibition in colon cancer

Liang Qiao, Yun Dai, Qing Gu, Kwok Wah Chan, Bing Zou, Juan Ma, Jide Wang, Hui Y. Lan, and Benjamin C.Y. Wong
Mol Cancer Ther 2008 7: 2203-2211 doi: 10.1158/1535-7163.MCT-08-0326 [Abstract] [Full Text] [PDF]  

The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor–induced apoptosis

Shruti M. Raja, Shuzhen Chen, Ping Yue, Timothy M. Acker, Benjamin Lefkove, Jack L. Arbiser, Fadlo R. Khuri, and Shi-Yong Sun
Mol Cancer Ther 2008 7: 2212-2223 doi: 10.1158/1535-7163.MCT-07-2409 [Abstract] [Full Text] [PDF] Supplementary Material  

Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine

Meenakshi Upreti, Rong Chu, Elena Galitovskaya, Sherri K. Smart, and Timothy C. Chambers
Mol Cancer Ther 2008 7: 2224-2232 doi: 10.1158/1535-7163.MCT-07-2299 [Abstract] [Full Text] [PDF] Supplementary Material  

Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids

Margaret E. Ackerman, David Pawlowski, and K. Dane Wittrup
Mol Cancer Ther 2008 7: 2233-2240 doi: 10.1158/1535-7163.MCT-08-0067 [Abstract] [Full Text] [PDF]  

A rationally designed tyrosine hydroxylase DNA vaccine induces specific antineuroblastoma immunity

Nicole Huebener, Stefan Fest, Anne Strandsby, Elke Michalsky, Robert Preissner, Yan Zeng, Gerhard Gaedicke, and Holger N. Lode
Mol Cancer Ther 2008 7: 2241-2251 doi: 10.1158/1535-7163.MCT-08-0109 [Abstract] [Full Text] [PDF]  

Synergistic tumoricidal effect of combined hMUC1 vaccination and hNIS radioiodine gene therapy

Yong Hyun Jeon, Yun Choi, Sun Och Yoon, Chul Woo Kim, and June-Key Chung
Mol Cancer Ther 2008 7: 2252-2260 doi: 10.1158/1535-7163.MCT-08-0277 [Abstract] [Full Text] [PDF] Supplementary Material  

Correction:

Article on CIC-3 and cancer drug resistance

Mol Cancer Ther 2008 7: 2261 doi: 10.1158/1535-7163.MCT-07-7-COR [Full Text] [PDF]  

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