Review:

Targeting the AKT protein kinase for cancer chemoprevention

James A. Crowell, Vernon E. Steele, and Judith R. Fay
Mol Cancer Ther 2007 6: 2139-2148 doi: 10.1158/1535-7163.MCT-07-0120 [Abstract] [Full Text] [PDF]  

Research Articles:

Bevacizumab plus 5-fluorouracil induce growth suppression in the CWR-22 and CWR-22R prostate cancer xenografts

Huynh Hung
Mol Cancer Ther 2007 6: 2149-2157 doi: 10.1158/1535-7163.MCT-07-0071 [Abstract] [Full Text] [PDF]  

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor growth in vivo

Qun-sheng Ji, Mark J. Mulvihill, Maryland Rosenfeld-Franklin, Andrew Cooke, Lixin Feng, Gilda Mak, Matthew O'Connor, Yan Yao, Caroline Pirritt, Elizabeth Buck, Alexandra Eyzaguirre, Lee D. Arnold, Neil W. Gibson, and Jonathan A. Pachter
Mol Cancer Ther 2007 6: 2158-2167Published Online First August 1, 2007. doi: 10.1158/1535-7163.MCT-07-0070 [Abstract] [Full Text] [PDF] Supplementary Material  

Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity

Fumiyuki Yamasaki, Dongwei Zhang, Chandra Bartholomeusz, Tamotsu Sudo, Gabriel N. Hortobagyi, Kaoru Kurisu, and Naoto T. Ueno
Mol Cancer Ther 2007 6: 2168-2177Published Online First August 1, 2007. doi: 10.1158/1535-7163.MCT-06-0514 [Abstract] [Full Text] [PDF]  

Selective cell death of oncogenic Akt-transduced brain cancer cells by etoposide through reactive oxygen species–mediated damage

Se-Yeong Oh, Young-Woo Sohn, Jong-Whi Park, Hyo-Jung Park, Hye-Min Jeon, Tae-Kyung Kim, Joong-Seob Lee, Ji-Eun Jung, Xun Jin, Yong Gu Chung, Young-Ki Choi, Seungkwon You, Jang-Bo Lee, and Hyunggee Kim
Mol Cancer Ther 2007 6: 2178-2187 doi: 10.1158/1535-7163.MCT-07-0111 [Abstract] [Full Text] [PDF]  

Rapamycin inhibits multiple stages of c-Neu/ErbB2–induced tumor progression in a transgenic mouse model of HER2-positive breast cancer

Jonathan D. Mosley, John T. Poirier, Darcie D. Seachrist, Melissa D. Landis, and Ruth A. Keri
Mol Cancer Ther 2007 6: 2188-2197 doi: 10.1158/1535-7163.MCT-07-0235 [Abstract] [Full Text] [PDF] Supplementary Material  

Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts

Neil R. Smith, Neil H. James, Ian Oakley, Anna Wainwright, Clive Copley, Jane Kendrew, Lynsey M. Womersley, Juliane M. Jürgensmeier, Stephen R. Wedge, and Simon T. Barry
Mol Cancer Ther 2007 6: 2198-2208 doi: 10.1158/1535-7163.MCT-07-0142 [Abstract] [Full Text] [PDF]  

AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models

Barry R. Davies, Armelle Logie, Jennifer S. McKay, Paul Martin, Samantha Steele, Richard Jenkins, Mark Cockerill, Sue Cartlidge, and Paul D. Smith
Mol Cancer Ther 2007 6: 2209-2219 doi: 10.1158/1535-7163.MCT-07-0231 [Abstract] [Full Text] [PDF]  

Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth

Honglin Hao, Vanessa M. Muniz-Medina, Heena Mehta, Nancy E. Thomas, Vladimir Khazak, Channing J. Der, and Janiel M. Shields
Mol Cancer Ther 2007 6: 2220-2229 doi: 10.1158/1535-7163.MCT-06-0728 [Abstract] [Full Text] [PDF]  

Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo

Ghenet K. Hagos, Robert E. Carroll, Tatiana Kouznetsova, Qian Li, Violeta Toader, Patricia A. Fernandez, Steven M. Swanson, and Gregory R.J. Thatcher
Mol Cancer Ther 2007 6: 2230-2239 doi: 10.1158/1535-7163.MCT-07-0069 [Abstract] [Full Text] [PDF]  

Therapeutic targeting of nuclear receptor corepressor misfolding in acute promyelocytic leukemia cells with genistein

Angela Ping Ping Ng, Dawn Sijin Nin, Jek Howe Fong, Divya Venkataraman, Chien-Shing Chen, and Matiullah Khan
Mol Cancer Ther 2007 6: 2240-2248 doi: 10.1158/1535-7163.MCT-06-0705 [Abstract] [Full Text] [PDF]  

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling

Chris R. Evelyn, Susan M. Wade, Qin Wang, Mei Wu, Jorge A. Iñiguez-Lluhí, Sofia D. Merajver, and Richard R. Neubig
Mol Cancer Ther 2007 6: 2249-2260 doi: 10.1158/1535-7163.MCT-06-0782 [Abstract] [Full Text] [PDF] Supplementary Data  

Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening data

David G. Covell, Ruili Huang, and Anders Wallqvist
Mol Cancer Ther 2007 6: 2261-2270 doi: 10.1158/1535-7163.MCT-06-0787 [Abstract] [Full Text] [PDF]  

Differentially expressed genes in radioresistant nasopharyngeal cancer cells: gp96 and GDF15

Joseph Tung-Chieh Chang, Shih-Hsuan Chan, Chien-Yu Lin, Ting-Yang Lin, Hung-Ming Wang, Chun-Ta Liao, Tzu-Hao Wang, Li-Yu Lee, and Ann-Joy Cheng
Mol Cancer Ther 2007 6: 2271-2279Published Online First August 1, 2007. doi: 10.1158/1535-7163.MCT-06-0801 [Abstract] [Full Text] [PDF]  

Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice

Urban Emmenegger, Yuval Shaked, Shan Man, Guido Bocci, Ivan Spasojevic, Giulio Francia, Andrew Kouri, Robert Coke, William Cruz-Munoz, Susan M. Ludeman, O. Michael Colvin, and Robert S. Kerbel
Mol Cancer Ther 2007 6: 2280-2289Published Online First August 1, 2007. doi: 10.1158/1535-7163.MCT-07-0181 [Abstract] [Full Text] [PDF]  

The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity

Sheila Miknyoczki, Hong Chang, Jennifer Grobelny, Sonya Pritchard, Candace Worrell, Natalie McGann, Mark Ator, Jean Husten, James Deibold, Robert Hudkins, Allison Zulli, Ralph Parchment, and Bruce Ruggeri
Mol Cancer Ther 2007 6: 2290-2302 doi: 10.1158/1535-7163.MCT-07-0062 [Abstract] [Full Text] [PDF]  

The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non–small cell lung carcinoma cells to DNA double-strand break–induced cell death

Anya G. Polischouk, Åsa Holgersson, Dali Zong, Bo Stenerlöw, Hanna L. Karlsson, Lennart Möller, Kristina Viktorsson, and Rolf Lewensohn
Mol Cancer Ther 2007 6: 2303-2309 doi: 10.1158/1535-7163.MCT-06-0402 [Abstract] [Full Text] [PDF]  

Alteration of dihydropyrimidine dehydrogenase expression by IFN- affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells

Shinji Oie, Mayumi Ono, Hiroto Fukushima, Fumihito Hosoi, Hirohisa Yano, Yuichiro Maruyama, Masamichi Kojiro, Tadafumi Terada, Kazuyuki Hirano, Michihiko Kuwano, and Yuji Yamada
Mol Cancer Ther 2007 6: 2310-2318 doi: 10.1158/1535-7163.MCT-06-0281 [Abstract] [Full Text] [PDF]  

A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-B, COX-1, and COX-2

Ann S.J. Yeoh, Rachel J. Gibson, Eric E.K. Yeoh, Joanne M. Bowen, Andrea M. Stringer, Kar A. Giam, and Dorothy M.K. Keefe
Mol Cancer Ther 2007 6: 2319-2327 doi: 10.1158/1535-7163.MCT-07-0113 [Abstract] [Full Text] [PDF]  

A bifunctional colchicinoid that binds to the androgen receptor

Nima Sharifi, Ernest Hamel, Markus A. Lill, Prabhakar Risbood, Charles T. Kane, Jr., Md Tafazzal Hossain, Amanda Jones, James T. Dalton, and William L. Farrar
Mol Cancer Ther 2007 6: 2328-2336 doi: 10.1158/1535-7163.MCT-07-0163 [Abstract] [Full Text] [PDF]  

A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

Arnold H. van der Luit, Stefan R. Vink, Jeffrey B. Klarenbeek, Daniel Perrissoud, Eric Solary, Marcel Verheij, and Wim J. van Blitterswijk
Mol Cancer Ther 2007 6: 2337-2345 doi: 10.1158/1535-7163.MCT-07-0202 [Abstract] [Full Text] [PDF]  

²¹³Bi-induced death of HSC45-M2 gastric cancer cells is characterized by G₂ arrest and up-regulation of genes known to prevent apoptosis but induce necrosis and mitotic catastrophe

Christof Seidl, Matthias Port, Klaus-Peter Gilbertz, Alfred Morgenstern, Frank Bruchertseifer, Markus Schwaiger, Barbara Röper, Reingard Senekowitsch-Schmidtke, and Michael Abend
Mol Cancer Ther 2007 6: 2346-2359 doi: 10.1158/1535-7163.MCT-07-0132 [Abstract] [Full Text] [PDF]  

Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma–associated herpesvirus

Tamara K. Nun, David J. Kroll, Nicholas H. Oberlies, Djaja D. Soejarto, Ryan J. Case, Pius Piskaut, Teatulohi Matainaho, Chelsey Hilscher, Ling Wang, Dirk P. Dittmer, Shou-Jian Gao, and Blossom Damania
Mol Cancer Ther 2007 6: 2360-2370 doi: 10.1158/1535-7163.MCT-07-0108 [Abstract] [Full Text] [PDF]  

Therapeutic ultrasound facilitates antiangiogenic gene delivery and inhibits prostate tumor growth

Maayan Duvshani-Eshet, Ofra Benny, Avigail Morgenstern, and Marcelle Machluf
Mol Cancer Ther 2007 6: 2371-2382 doi: 10.1158/1535-7163.MCT-07-0019 [Abstract] [Full Text] [PDF]  

Correction:

Article on TNF-—based accentuation in cryoinjury

Mol Cancer Ther 2007 6: 2383 doi: 10.1158/1535-7163.MCT-6-8-COR [Full Text] [PDF]  

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