Spotlight on Molecular Profiling:

Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells

William C. Reinhold, Mark A. Reimers, Alika K. Maunakea, Sohyoung Kim, Samir Lababidi, Uwe Scherf, Uma T. Shankavaram, Micah S. Ziegler, Claudia Stewart, Hosein Kouros-Mehr, Hengmi Cui, Douglas Dolginow, Dominic A. Scudiero, Yves G. Pommier, David J. Munroe, Andrew P. Feinberg, and John N. Weinstein
Mol Cancer Ther 2007 6: 391-403Published Online First February 1, 2007. doi: 10.1158/1535-7163.MCT-06-0609 [Abstract] [Full Text] [PDF]  

Reviews:

Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

Shrikanta Chattopadhyay, Richard G. Moran, and I. David Goldman
Mol Cancer Ther 2007 6: 404-417 doi: 10.1158/1535-7163.MCT-06-0343 [Abstract] [Full Text] [PDF]  

Why should we still care about oncogenes?

Kathleen M. Diehl, Evan T. Keller, and Kathleen M. Woods Ignatoski
Mol Cancer Ther 2007 6: 418-427 doi: 10.1158/1535-7163.MCT-06-0603 [Abstract] [Full Text] [PDF]  

The application of cassette dosing for pharmacokinetic screening in small-molecule cancer drug discovery

Nicola F. Smith, Florence I. Raynaud, and Paul Workman
Mol Cancer Ther 2007 6: 428-440 doi: 10.1158/1535-7163.MCT-06-0324 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

Plasminogen Kringle 5 blocks tumor progression by antiangiogenic and proinflammatory pathways

Sabrina R. Perri, Daniel Martineau, Moïra François, Laurence Lejeune, Louis Bisson, Yves Durocher, and Jacques Galipeau
Mol Cancer Ther 2007 6: 441-449 doi: 10.1158/1535-7163.MCT-06-0434 [Abstract] [Full Text] [PDF]  

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1

Timothy J. Lansing, Randy T. McConnell, Derek R. Duckett, Glenn M. Spehar, Victoria B. Knick, Daniel F. Hassler, Nobuhiro Noro, Masaaki Furuta, Kyle A. Emmitte, Tona M. Gilmer, Robert A. Mook, Jr., and Mui Cheung
Mol Cancer Ther 2007 6: 450-459Published Online First January 31, 2007. doi: 10.1158/1535-7163.MCT-06-0543 [Abstract] [Full Text] [PDF]  

The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA

Mi-Ae Lyu, Lawrence H. Cheung, Walter N. Hittelman, John W. Marks, Ricardo C.T. Aguiar, and Michael G. Rosenblum
Mol Cancer Ther 2007 6: 460-470Published Online First January 31, 2007. doi: 10.1158/1535-7163.MCT-06-0254 [Abstract] [Full Text] [PDF]  

Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade

Wenjuan Wu, Amir Onn, Takeshi Isobe, Satoshi Itasaka, Robert R. Langley, Tomoaki Shitani, Keiko Shibuya, Ritsuko Komaki, Anderson J. Ryan, Isaiah J. Fidler, Roy S. Herbst, and Michael S. O'Reilly
Mol Cancer Ther 2007 6: 471-483 doi: 10.1158/1535-7163.MCT-06-0416 [Abstract] [Full Text] [PDF]  

R16, a novel amonafide analogue, induces apoptosis and G₂-M arrest via poisoning topoisomerase II

Hong Zhu, Min Huang, Fan Yang, Yi Chen, Ze-Hong Miao, Xu-Hong Qian, Yu-Fang Xu, Yu-Xin Qin, Hai-Bin Luo, Xu Shen, Mei-Yu Geng, Yu-Jun Cai, and Jian Ding
Mol Cancer Ther 2007 6: 484-495 doi: 10.1158/1535-7163.MCT-06-0584 [Abstract] [Full Text] [PDF]  

The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems

Merrill E. Goldsmith, Alian Aguila, Kenneth Steadman, Alfredo Martinez, Seth M. Steinberg, Michael C. Alley, William R. Waud, Susan E. Bates, and Tito Fojo
Mol Cancer Ther 2007 6: 496-505 doi: 10.1158/1535-7163.MCT-06-0431 [Abstract] [Full Text] [PDF]  

The NC1 domain of type XIX collagen inhibits in vivo melanoma growth

Laurent Ramont, Sylvie Brassart-Pasco, Jessica Thevenard, Aurélie Deshorgue, Lydie Venteo, Jean Yves Laronze, Michel Pluot, Jean-Claude Monboisse, and François-Xavier Maquart
Mol Cancer Ther 2007 6: 506-514 doi: 10.1158/1535-7163.MCT-06-0207 [Abstract] [Full Text] [PDF]  

Optimizing the development of targeted agents in pancreatic cancer: tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays

Belen Rubio-Viqueira, Heather Mezzadra, Matthew E. Nielsen, Antonio Jimeno, Xianfeng Zhang, Christine Iacobuzio-Donahue, Anirban Maitra, Manuel Hidalgo, and Soner Altiok
Mol Cancer Ther 2007 6: 515-523 doi: 10.1158/1535-7163.MCT-06-0388 [Abstract] [Full Text] [PDF]  

Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts

Alice P. Taylor and David M. Goldenberg
Mol Cancer Ther 2007 6: 524-531 doi: 10.1158/1535-7163.MCT-06-0461 [Abstract] [Full Text] [PDF] Supplementary Material, Taylor  

Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition

Elizabeth Buck, Alexandra Eyzaguirre, Sharon Barr, Stuart Thompson, Regina Sennello, David Young, Kenneth K. Iwata, Neil W. Gibson, Pablo Cagnoni, and John D. Haley
Mol Cancer Ther 2007 6: 532-541 doi: 10.1158/1535-7163.MCT-06-0462 [Abstract] [Full Text] [PDF]  

Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer

Chie Suzuki, Koji Takahashi, Satoshi Hayama, Nobuhisa Ishikawa, Tatsuya Kato, Tomoo Ito, Eiju Tsuchiya, Yusuke Nakamura, and Yataro Daigo
Mol Cancer Ther 2007 6: 542-551 doi: 10.1158/1535-7163.MCT-06-0659 [Abstract] [Full Text] [PDF]  

A novel three-dimensional model to quantify metastatic melanoma invasion

Cyrus M. Ghajar, Vinod Suresh, Shelly R. Peyton, Christopher B. Raub, Frank L. Meyskens, Jr., Steven C. George, and Andrew J. Putnam
Mol Cancer Ther 2007 6: 552-561Published Online First January 31, 2007. doi: 10.1158/1535-7163.MCT-06-0593 [Abstract] [Full Text] [PDF]  

Target-specific cytotoxic activity of recombinant immunotoxin scFv(MUC1)-ETA on breast carcinoma cells and primary breast tumors

Ravibhushan Singh, Urmila Samant, Stephen Hyland, Pradip R. Chaudhari, Winfried S. Wels, and Dilip Bandyopadhyay
Mol Cancer Ther 2007 6: 562-569 doi: 10.1158/1535-7163.MCT-06-0604 [Abstract] [Full Text] [PDF]  

Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect

Yuval Sheffer, Oded Leon, Jehonathan H. Pinthus, Arnon Nagler, Yoram Mor, Olga Genin, Maya Iluz, Norifumi Kawada, Katsutoshi Yoshizato, and Mark Pines
Mol Cancer Ther 2007 6: 570-577Published Online First January 31, 2007. doi: 10.1158/1535-7163.MCT-06-0468 [Abstract] [Full Text] [PDF]  

Prediction of drug combination chemosensitivity in human bladder cancer

Dmytro M. Havaleshko, HyungJun Cho, Mark Conaway, Charles R. Owens, Garret Hampton, Jae K. Lee, and Dan Theodorescu
Mol Cancer Ther 2007 6: 578-586 doi: 10.1158/1535-7163.MCT-06-0497 [Abstract] [Full Text] [PDF]  

Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells

Noel R. Monks, Shuqian Liu, Yongsheng Xu, Hui Yu, Adam S. Bendelow, and Jeffrey A. Moscow
Mol Cancer Ther 2007 6: 587-598 doi: 10.1158/1535-7163.MCT-06-0500 [Abstract] [Full Text] [PDF]  

Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit

Kaye J. Williams, Brian A. Telfer, Aoife M. Shannon, Muhammad Babur, Ian J. Stratford, and Stephen R. Wedge
Mol Cancer Ther 2007 6: 599-606 doi: 10.1158/1535-7163.MCT-06-0508 [Abstract] [Full Text] [PDF]  

Functional evaluation of novel soluble insulin-like growth factor (IGF)-II–specific ligand traps based on modified domain 11 of the human IGF2 receptor

Stuart N. Prince, Emily J. Foulstone, Oliver J. Zaccheo, Christopher Williams, and Andrew Bassim Hassan
Mol Cancer Ther 2007 6: 607-617 doi: 10.1158/1535-7163.MCT-06-0509 [Abstract] [Full Text] [PDF]  

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

Clint Mitchell, Margaret A. Park, Guo Zhang, Song Iy Han, Hisashi Harada, Richard A. Franklin, Adly Yacoub, Pin-Lan Li, Philip B. Hylemon, Steven Grant, and Paul Dent
Mol Cancer Ther 2007 6: 618-632 doi: 10.1158/1535-7163.MCT-06-0532 [Abstract] [Full Text] [PDF]  

Gene expression analysis of gallium-resistant and gallium-sensitive lymphoma cells reveals a role for metal-responsive transcription factor-1, metallothionein-2A, and zinc transporter-1 in modulating the antineoplastic activity of gallium nitrate

Meiying Yang, Steven H. Kroft, and Christopher R. Chitambar
Mol Cancer Ther 2007 6: 633-643 doi: 10.1158/1535-7163.MCT-06-0557 [Abstract] [Full Text] [PDF]  

Effect of frequently used chemotherapeutic drugs on the cytotoxic activity of human natural killer cells

Laszlo Markasz, Gyorgy Stuber, Bruno Vanherberghen, Emilie Flaberg, Eva Olah, Ennio Carbone, Staffan Eksborg, Eva Klein, Henriette Skribek, and Laszlo Szekely
Mol Cancer Ther 2007 6: 644-654 doi: 10.1158/1535-7163.MCT-06-0358 [Abstract] [Full Text] [PDF]  

Novel compounds with antiproliferative activity against imatinib-resistant cell lines

Enrica I. Lerma, Viet-Anh Nguyen, Tao Wang, Alex Tipping, Junia V. Melo, Donald Kufe, David J. Austin, and Albert Deisseroth
Mol Cancer Ther 2007 6: 655-666Published Online First January 31, 2007. doi: 10.1158/1535-7163.MCT-04-0307 [Abstract] [Full Text] [PDF]  

Lapatinib induces apoptosis in trastuzumab-resistant breast cancer cells: effects on insulin-like growth factor I signaling

Rita Nahta, Linda X.H. Yuan, Yi Du, and Francisco J. Esteva
Mol Cancer Ther 2007 6: 667-674 doi: 10.1158/1535-7163.MCT-06-0423 [Abstract] [Full Text] [PDF]  

Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor B

Dong Ju Son, Mi Hee Park, Sang Jin Chae, Soon Ok Moon, Jae Woong Lee, Ho Sueb Song, Dong Cheul Moon, Sang Sun Kang, Young Ee Kwon, and Jin Tae Hong
Mol Cancer Ther 2007 6: 675-683 doi: 10.1158/1535-7163.MCT-06-0328 [Abstract] [Full Text] [PDF]  

Disrupting Skp2-cyclin A interaction with a blocking peptide induces selective cancer cell killing

Peng Ji, Daqian Sun, Hongbo Wang, Frederick Bauzon, and Liang Zhu
Mol Cancer Ther 2007 6: 684-691 doi: 10.1158/1535-7163.MCT-06-0538 [Abstract] [Full Text] [PDF]  

Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions

Roberto R. Rosato, Jorge A. Almenara, Sarah S. Kolla, Sonia C. Maggio, Stefanie Coe, Maria S. Giménez, Paul Dent, and Steven Grant
Mol Cancer Ther 2007 6: 692-702 doi: 10.1158/1535-7163.MCT-06-0562 [Abstract] [Full Text] [PDF]  

Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells

Sergey V. Krysov, Tania F. Rowley, and Aymen Al-Shamkhani
Mol Cancer Ther 2007 6: 703-711 doi: 10.1158/1535-7163.MCT-06-0544 [Abstract] [Full Text] [PDF]  

Role of human longevity assurance gene 1 and C₁₈-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

Can E. Senkal, Suriyan Ponnusamy, Michael J. Rossi, Jacek Bialewski, Debijyati Sinha, James C. Jiang, S. Michal Jazwinski, Yusuf A. Hannun, and Besim Ogretmen
Mol Cancer Ther 2007 6: 712-722 doi: 10.1158/1535-7163.MCT-06-0558 [Abstract] [Full Text] [PDF]  

Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor-B in acute myeloid leukemia–derived predendritic KG-1 cells

Malte Bachmann, Cristina Dragoi, Marco A. Poleganov, Josef Pfeilschifter, and Heiko Mühl
Mol Cancer Ther 2007 6: 723-731 doi: 10.1158/1535-7163.MCT-06-0505 [Abstract] [Full Text] [PDF]  

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose

Johnathan C. Maher, Medhi Wangpaichitr, Niramol Savaraj, Metin Kurtoglu, and Theodore J. Lampidis
Mol Cancer Ther 2007 6: 732-741 doi: 10.1158/1535-7163.MCT-06-0407 [Abstract] [Full Text] [PDF]  

Treatment of prostate cancer with Ad5/324hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo

Maria Rajecki, Anna Kanerva, Ulf-Håkan Stenman, Mikko Tenhunen, Lotta Kangasniemi, Merja Särkioja, Martti Y. Ala-Opas, Henrik Alfthan, Anna Sankila, Erkki Rintala, Renee A. Desmond, Tanja Hakkarainen, and Akseli Hemminki
Mol Cancer Ther 2007 6: 742-751 doi: 10.1158/1535-7163.MCT-06-0403 [Abstract] [Full Text] [PDF]  

Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2

Nizar M. Mhaidat, Yufang Wang, Kelly A. Kiejda, Xu Dong Zhang, and Peter Hersey
Mol Cancer Ther 2007 6: 752-761 doi: 10.1158/1535-7163.MCT-06-0564 [Abstract] [Full Text] [PDF]  

Sensitization of p53-mutated epithelial ovarian cancer to CD95-mediated apoptosis is synergistically induced by cisplatin pretreatment

Marina Bagnoli, Emanuela Balladore, Elena Luison, Paola Alberti, Francesco Raspagliesi, Barbara Marcomini, Silvana Canevari, and Delia Mezzanzanica
Mol Cancer Ther 2007 6: 762-772 doi: 10.1158/1535-7163.MCT-06-0357 [Abstract] [Full Text] [PDF]  

Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells

Mike Failly, Serdar Korur, Viviane Egler, Jean-Louis Boulay, Maria Maddalena Lino, Roland Imber, and Adrian Merlo
Mol Cancer Ther 2007 6: 773-781 doi: 10.1158/1535-7163.MCT-06-0566 [Abstract] [Full Text] [PDF]  

HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells

Katrin Mani, Staffan Sandgren, Johanna Lilja, Fang Cheng, Katrin Svensson, Lo Persson, and Mattias Belting
Mol Cancer Ther 2007 6: 782-788 doi: 10.1158/1535-7163.MCT-06-0370 [Abstract] [Full Text] [PDF]  

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