Research Articles: Therapeutics, Targets, and Development:

Inhibition of Src family kinases enhances retinoic acid–induced gene expression and myeloid differentiation

Michelle B. Miranda, Robert L. Redner, and Daniel E. Johnson
Mol Cancer Ther 2007 6: 3081-3090Published Online First December 7, 2007. doi: 10.1158/1535-7163.MCT-07-0514 [Abstract] [Full Text] [PDF]  

In vitro expansion of human breast cancer epithelial and mesenchymal stromal cells: optimization of a coculture model for personalized therapy approaches

Bianca Maria Veneziani, Vittoria Criniti, Carla Cavaliere, Sara Corvigno, Agostina Nardone, Silvia Picarelli, Giampaolo Tortora, Fortunato Ciardiello, Gennaro Limite, and Sabino De Placido
Mol Cancer Ther 2007 6: 3091-3100 doi: 10.1158/1535-7163.MCT-07-0356 [Abstract] [Full Text] [PDF]  

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

Clint Mitchell, Maragret A. Park, Guo Zhang, Adly Yacoub, David T. Curiel, Paul B. Fisher, John D. Roberts, Steven Grant, and Paul Dent
Mol Cancer Ther 2007 6: 3101-3112Published Online First December 7, 2007. doi: 10.1158/1535-7163.MCT-07-0561 [Abstract] [Full Text] [PDF]  

Inactivation of glycogen synthase kinase-3β contributes to brain-derived neutrophic factor/TrkB-induced resistance to chemotherapy in neuroblastoma cells

Zhijie Li, Fei Tan, and Carol J. Thiele
Mol Cancer Ther 2007 6: 3113-3121 doi: 10.1158/1535-7163.MCT-07-0133 [Abstract] [Full Text] [PDF]  

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1–targeted tripartite quinone drug delivery system

Milène Volpato, Nathalie Abou-Zeid, Richard W. Tanner, Lee T. Glassbrook, James Taylor, Ian Stratford, Paul M. Loadman, Mohammed Jaffar, and Roger M. Phillips
Mol Cancer Ther 2007 6: 3122-3130 doi: 10.1158/1535-7163.MCT-07-0519 [Abstract] [Full Text] [PDF]  

Antineoplastic agents target the 25-hydroxyvitamin D₃ 24-hydroxylase messenger RNA for degradation: implications in anticancer activity

Joseph Tan, Prem P. Dwivedi, Paul Anderson, Barbara K. Nutchey, Peter O'Loughlin, Howard A. Morris, Brian K. May, Antonio Ferrante, and Charles S. Hii
Mol Cancer Ther 2007 6: 3131-3138 doi: 10.1158/1535-7163.MCT-07-0427 [Abstract] [Full Text] [PDF]  

The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent

Nicola Vannini, Girieca Lorusso, Rosaria Cammarota, Massimo Barberis, Douglas M. Noonan, Michael B. Sporn, and Adriana Albini
Mol Cancer Ther 2007 6: 3139-3146Published Online First December 7, 2007. doi: 10.1158/1535-7163.MCT-07-0451 [Abstract] [Full Text] [PDF]  

Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity

Florence Chan, Chongbo Sun, Meg Perumal, Quang-De Nguyen, Vassilios Bavetsias, Edward McDonald, Vanessa Martins, Nicola E. Wilsher, Florence I. Raynaud, Melanie Valenti, Sue Eccles, Robert te Poele, Paul Workman, Eric O. Aboagye, and Spiros Linardopoulos
Mol Cancer Ther 2007 6: 3147-3157 doi: 10.1158/1535-7163.MCT-07-2156 [Abstract] [Full Text] [PDF]  

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

Patrizia Carpinelli, Roberta Ceruti, Maria Laura Giorgini, Paolo Cappella, Laura Gianellini, Valter Croci, Anna Degrassi, Gemma Texido, Maurizio Rocchetti, Paola Vianello, Luisa Rusconi, Paola Storici, Paola Zugnoni, Claudio Arrigoni, Chiara Soncini, Cristina Alli, Veronica Patton, Aurelio Marsiglio, Dario Ballinari, Enrico Pesenti, Daniele Fancelli, and Jürgen Moll
Mol Cancer Ther 2007 6: 3158-3168 doi: 10.1158/1535-7163.MCT-07-0444 [Abstract] [Full Text] [PDF] Supplementary Data  

The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells

Janna Krol, Richard E. Francis, André Albergaria, Andrew Sunters, Andreas Polychronis, R. Charles Coombes, and Eric W.-F. Lam
Mol Cancer Ther 2007 6: 3169-3179 doi: 10.1158/1535-7163.MCT-07-0507 [Abstract] [Full Text] [PDF]  

Chemosensitization of head and neck cancer cells by PUMA

Quanhong Sun, Tsukasa Sakaida, Wen Yue, Susanne M. Gollin, and Jian Yu
Mol Cancer Ther 2007 6: 3180-3188 doi: 10.1158/1535-7163.MCT-07-0265 [Abstract] [Full Text] [PDF]  

Cell type–dependent effects of Polo-like kinase 1 inhibition compared with targeted polo box interference in cancer cell lines

Jenny Fink, Karl Sanders, Alexandra Rippl, Sylvia Finkernagel, Thomas L. Beckers, and Mathias Schmidt
Mol Cancer Ther 2007 6: 3189-3197 doi: 10.1158/1535-7163.MCT-07-0048 [Abstract] [Full Text] [PDF]  

TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth

Leo Christopher DeRosier, Selwyn M. Vickers, Kurt R. Zinn, Zhi Huang, Wenquan Wang, William E. Grizzle, Jeffrey Sellers, Cecil R. Stockard, Jr., Tong Zhou, Patsy G. Oliver, Pablo Arnoletti, Albert F. LoBuglio, and Donald J. Buchsbaum
Mol Cancer Ther 2007 6: 3198-3207 doi: 10.1158/1535-7163.MCT-07-0299 [Abstract] [Full Text] [PDF]  

A novel, potent, and specific ephrinA1-based cytotoxin against EphA2 receptor–expressing tumor cells

Jill Wykosky, Denise M. Gibo, and Waldemar Debinski
Mol Cancer Ther 2007 6: 3208-3218 doi: 10.1158/1535-7163.MCT-07-0200 [Abstract] [Full Text] [PDF]  

Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis

Rachel M. Locklin, Ermanno Federici, Belen Espina, Philippa A. Hulley, R. Graham G. Russell, and Claire M. Edwards
Mol Cancer Ther 2007 6: 3219-3228Published Online First December 7, 2007. doi: 10.1158/1535-7163.MCT-07-0275 [Abstract] [Full Text] [PDF]  

Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters

Kazutaka Takagi, Thomas S. Dexheimer, Christophe Redon, Olivier Sordet, Keli Agama, Gilbert Lavielle, Alain Pierré, Susan E. Bates, and Yves Pommier
Mol Cancer Ther 2007 6: 3229-3238 doi: 10.1158/1535-7163.MCT-07-0441 [Abstract] [Full Text] [PDF]  

Efficacy and tissue distribution of DHP107, an oral paclitaxel formulation

Jung Wan Hong, In-Hyun Lee, Young Hak Kwak, Young Taek Park, Ha Chin Sung, Ick Chan Kwon, and Hesson Chung
Mol Cancer Ther 2007 6: 3239-3247 doi: 10.1158/1535-7163.MCT-07-0261 [Abstract] [Full Text] [PDF]  

Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine–induced urinary bladder carcinogenesis in male ICR mice

Alpna Tyagi, Komal Raina, Rana P. Singh, Mallikarjuna Gu, Chapla Agarwal, Gail Harrison, L. Michael Glode, and Rajesh Agarwal
Mol Cancer Ther 2007 6: 3248-3255 doi: 10.1158/1535-7163.MCT-07-2006 [Abstract] [Full Text] [PDF]  

Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma

Claudio Scavelli, Giulia Di Pietro, Teresa Cirulli, Mauro Coluccia, Angela Boccarelli, Teresa Giannini, Giuseppe Mangialardi, Raffaello Bertieri, Addolorata Maria Luce Coluccia, Domenico Ribatti, Franco Dammacco, and Angelo Vacca
Mol Cancer Ther 2007 6: 3256-3262 doi: 10.1158/1535-7163.MCT-07-0311 [Abstract] [Full Text] [PDF]  

Zoledronic acid inhibits osteosarcoma growth in an orthotopic model

Crispin R. Dass and Peter F.M. Choong
Mol Cancer Ther 2007 6: 3263-3270 doi: 10.1158/1535-7163.MCT-07-0546 [Abstract] [Full Text] [PDF]  

New inhibitors of ABCG2 identified by high-throughput screening

Curtis J. Henrich, Robert W. Robey, Heidi R. Bokesch, Susan E. Bates, Suneet Shukla, Suresh V. Ambudkar, Michael Dean, and James B. McMahon
Mol Cancer Ther 2007 6: 3271-3278 doi: 10.1158/1535-7163.MCT-07-0352 [Abstract] [Full Text] [PDF]  

The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance–linked ATP binding cassette drug transporter ABCG2

Suneet Shukla, Chung-Pu Wu, Krishnamachary Nandigama, and Suresh V. Ambudkar
Mol Cancer Ther 2007 6: 3279-3286Published Online First December 7, 2007. doi: 10.1158/1535-7163.MCT-07-0564 [Abstract] [Full Text] [PDF]  

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter

Chung-Pu Wu, Suneet Shukla, Anna Maria Calcagno, Matthew D. Hall, Michael M. Gottesman, and Suresh V. Ambudkar
Mol Cancer Ther 2007 6: 3287-3296 doi: 10.1158/1535-7163.MCT-07-2005 [Abstract] [Full Text] [PDF]  

Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis

Baohe Zhu, Lei Lu, Weibin Cai, Xia Yang, Chaoyang Li, Zhonghan Yang, Wenhua Zhan, Jian-xing Ma, and Guoquan Gao
Mol Cancer Ther 2007 6: 3297-3306 doi: 10.1158/1535-7163.MCT-06-0798 [Abstract] [Full Text] [PDF]  

In vitro transport of gimatecan (7-t-butoxyiminomethylcamptothecin) by breast cancer resistance protein, P-glycoprotein, and multidrug resistance protein 2

Serena Marchetti, Roos L. Oostendorp, Dick Pluim, Monique van Eijndhoven, Olaf van Tellingen, Alfred H. Schinkel, Richard Versace, Jos H. Beijnen, Roberto Mazzanti, and Jan H. Schellens
Mol Cancer Ther 2007 6: 3307-3313 doi: 10.1158/1535-7163.MCT-07-0461 [Abstract] [Full Text] [PDF]  

Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

James G. Christensen, Helen Y. Zou, Maria E. Arango, Qiuhua Li, Joseph H. Lee, Scott R. McDonnell, Shinji Yamazaki, Gordon R. Alton, Barbara Mroczkowski, and Gerrit Los
Mol Cancer Ther 2007 6: 3314-3322 doi: 10.1158/1535-7163.MCT-07-0365 [Abstract] [Full Text] [PDF]  

Mol Cancer Ther 2007 6: 3323-3329 doi: 10.1158/1535-7163.MCT-6-12-ACK [Full Text] [PDF]  

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