Commentary:

Liposomal delivery as a mechanism to enhance synergism between anticancer drugs

Robert J. Lee
Mol Cancer Ther 2006 5: 1639-1640 doi: 10.1158/1535-7163.MCT-06-C02 [Full Text] [PDF]  

Review:

Pigment epithelium-derived factor: a multimodal tumor inhibitor

Eugene T.H. Ek, Crispin R. Dass, and Peter F.M. Choong
Mol Cancer Ther 2006 5: 1641-1646 doi: 10.1158/1535-7163.MCT-06-0107 [Abstract] [Full Text] [PDF]  

Research Articles: Targets:

Discovery and characterization of inhibitors of human palmitoyl acyltransferases

Charles E. Ducker, Lindsay K. Griffel, Ryan A. Smith, Staci N. Keller, Yan Zhuang, Zuping Xia, John D. Diller, and Charles D. Smith
Mol Cancer Ther 2006 5: 1647-1659 doi: 10.1158/1535-7163.MCT-06-0114 [Abstract] [Full Text] [PDF]  

Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice

Syed M. Meeran, Suchitra Katiyar, Craig A. Elmets, and Santosh K. Katiyar
Mol Cancer Ther 2006 5: 1660-1668 doi: 10.1158/1535-7163.MCT-06-0095 [Abstract] [Full Text] [PDF]  

Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cells

Maria Antonietta Cerone, J. Arturo Londoño-Vallejo, and Chantal Autexier
Mol Cancer Ther 2006 5: 1669-1675 doi: 10.1158/1535-7163.MCT-06-0033 [Abstract] [Full Text] [PDF]  

Regulatory role of c-Met in insulin-like growth factor-I receptor–mediated migration and invasion of human pancreatic carcinoma cells

Todd W. Bauer, Ray J. Somcio, Fan Fan, Wenbiao Liu, Marjorie Johnson, Donald P. Lesslie, Douglas B. Evans, Gary E. Gallick, and Lee M. Ellis
Mol Cancer Ther 2006 5: 1676-1682 doi: 10.1158/1535-7163.MCT-05-0175 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics:

Antisense locked nucleic acids efficiently suppress BCR/ABL and induce cell growth decline and apoptosis in leukemic cells

Valentina Rapozzi, Susanna Cogoi, and Luigi E. Xodo
Mol Cancer Ther 2006 5: 1683-1692 doi: 10.1158/1535-7163.MCT-06-0006 [Abstract] [Full Text] [PDF]  

CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo

Z. Alexander Cao, Kathryn E. Bass, Sriram Balasubramanian, Liang Liu, Brian Schultz, Erik Verner, YuQin Dai, Rafael A. Molina, Jack R. Davis, Shawn Misialek, Martin Sendzik, Christine J. Orr, Ling Leung, Ondine Callan, Peter Young, Stacie A. Dalrymple, and Joseph J. Buggy
Mol Cancer Ther 2006 5: 1693-1701 doi: 10.1158/1535-7163.MCT-06-0042 [Abstract] [Full Text] [PDF]  

5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo

Donna L. Dehn, David Siegel, Khan Shoeb Zafar, Philip Reigan, Elizabeth Swann, Christopher J. Moody, and David Ross
Mol Cancer Ther 2006 5: 1702-1709 doi: 10.1158/1535-7163.MCT-06-0105 [Abstract] [Full Text] [PDF]  

A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats

Emmanuel Garcion, Alf Lamprecht, Béatrice Heurtault, Archibald Paillard, Anne Aubert-Pouessel, Benoît Denizot, Philippe Menei, and Jean-Pierre Benoît
Mol Cancer Ther 2006 5: 1710-1722 doi: 10.1158/1535-7163.MCT-06-0289 [Abstract] [Full Text] [PDF]  

Mannosylated chitosan nanoparticle–based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells

Tae Hee Kim, Hua Jin, Hyun Woo Kim, Myung-Haing Cho, and Chong Su Cho
Mol Cancer Ther 2006 5: 1723-1732 doi: 10.1158/1535-7163.MCT-05-0540 [Abstract] [Full Text] [PDF]  

Blockade of transforming growth factor-ß signaling in tumor-reactive CD8⁺ T cells activates the antitumor immune response cycle

Qiang Zhang, Ximing J. Yang, Shilajit D. Kundu, Michael Pins, Borko Javonovic, Robert Meyer, Seong-Jin Kim, Norman M. Greenberg, Timothy Kuzel, Richard Meagher, Yinglu Guo, and Chung Lee
Mol Cancer Ther 2006 5: 1733-1743 doi: 10.1158/1535-7163.MCT-06-0109 [Abstract] [Full Text] [PDF]  

The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice

Susan Jones-Bolin, Hugh Zhao, Kathryn Hunter, Andres Klein-Szanto, and Bruce Ruggeri
Mol Cancer Ther 2006 5: 1744-1753 doi: 10.1158/1535-7163.MCT-05-0327 [Abstract] [Full Text] [PDF]  

Effect of an epidermal growth factor receptor tyrosine kinase inhibitor on actin remodeling in an in vitro bladder cancer carcinogenesis model

Yusheng Jin, Kenneth K. Iwata, Arie Belldegrun, Robert Figlin, Allan Pantuck, Zuo-Feng Zhang, Ronald Lieberman, and Jianyu Rao
Mol Cancer Ther 2006 5: 1754-1763 doi: 10.1158/1535-7163.MCT-06-0043 [Abstract] [Full Text] [PDF]  

Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach

Steven L. Warner, Sridevi Bashyam, Hariprasad Vankayalapati, David J. Bearss, Haiyong Han, Daniel D. Von Hoff, and Laurence H. Hurley
Mol Cancer Ther 2006 5: 1764-1773 doi: 10.1158/1535-7163.MCT-05-0524 [Abstract] [Full Text] [PDF]  

SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity

Shem Patyna, A. Douglas Laird, Dirk B. Mendel, Anne-Marie O'Farrell, Chris Liang, Huiping Guan, Tomas Vojkovsky, Stefan Vasile, Xueyan Wang, Jeffrey Chen, Maren Grazzini, Cheng Y. Yang, Joshua Ö. Haznedar, Juthamas Sukbuntherng, Wei-Zhu Zhong, Julie M. Cherrington, and Dana Hu-Lowe
Mol Cancer Ther 2006 5: 1774-1782 doi: 10.1158/1535-7163.MCT-05-0333 [Abstract] [Full Text] [PDF]  

Enzastaurin (LY317615), a protein kinase Cß inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines

Mujahid A. Rizvi, Kulsoom Ghias, Katharine M. Davies, Chunguang Ma, Frank Weinberg, Hidayatullah G. Munshi, Nancy L. Krett, and Steven T. Rosen
Mol Cancer Ther 2006 5: 1783-1789 doi: 10.1158/1535-7163.MCT-05-0465 [Abstract] [Full Text] [PDF]  

AGRO100 inhibits activation of nuclear factor-B (NF-B) by forming a complex with NF-B essential modulator (NEMO) and nucleolin

Allicia C. Girvan, Yun Teng, Lavona K. Casson, Shelia D. Thomas, Simone Jüliger, Mark W. Ball, Jon B. Klein, William M. Pierce, Jr., Shirish S. Barve, and Paula J. Bates
Mol Cancer Ther 2006 5: 1790-1799 doi: 10.1158/1535-7163.MCT-05-0361 [Abstract] [Full Text] [PDF]  

The determinants of sensitivity and acquired resistance to gemcitabine differ in non–small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity

Tetsuya Oguri, Hiroyuki Achiwa, Shigeki Sato, Yuji Bessho, Yuko Takano, Mikinori Miyazaki, Hideki Muramatsu, Hiroyoshi Maeda, Takashi Niimi, and Ryuzo Ueda
Mol Cancer Ther 2006 5: 1800-1806 doi: 10.1158/1535-7163.MCT-06-0025 [Abstract] [Full Text] [PDF]  

Cyclohexylpiperazine derivative PB28, a ₂ agonist and ₁ antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer

Amalia Azzariti, Nicola A. Colabufo, Francesco Berardi, Letizia Porcelli, Mauro Niso, Grazia M. Simone, Roberto Perrone, and Angelo Paradiso
Mol Cancer Ther 2006 5: 1807-1816 doi: 10.1158/1535-7163.MCT-05-0402 [Abstract] [Full Text] [PDF]  

Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E₂–dependent activation of type II protein kinase A

Troy Payner, H. Anne Leaver, Brian Knapp, Ian R. Whittle, Ovidiu C. Trifan, Steven Miller, and Maria Teresa Rizzo
Mol Cancer Ther 2006 5: 1817-1826 doi: 10.1158/1535-7163.MCT-05-0548 [Abstract] [Full Text] [PDF]  

15-Deoxy-^12,14-prostaglandin J₂ induces death receptor 5 expression through mRNA stabilization independently of PPAR and potentiates TRAIL-induced apoptosis

Susumu Nakata, Tatsushi Yoshida, Takumi Shiraishi, Mano Horinaka, Junji Kouhara, Miki Wakada, and Toshiyuki Sakai
Mol Cancer Ther 2006 5: 1827-1835 doi: 10.1158/1535-7163.MCT-06-0023 [Abstract] [Full Text] [PDF]  

The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia

Stacey Ruiz, Yelena Krupnik, Michael Keating, Joya Chandra, Michael Palladino, and David McConkey
Mol Cancer Ther 2006 5: 1836-1843 doi: 10.1158/1535-7163.MCT-06-0066 [Abstract] [Full Text] [PDF]  

Multiple mechanisms underlie resistance of leukemia cells to Apo2 Ligand/TRAIL

Jinrong Cheng, Bonnie L. Hylander, Maria R. Baer, Xing Chen, and Elizabeth A. Repasky
Mol Cancer Ther 2006 5: 1844-1853 doi: 10.1158/1535-7163.MCT-06-0050 [Abstract] [Full Text] [PDF]  

Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice

Lawrence D. Mayer, Troy O. Harasym, Paul G. Tardi, Natashia L. Harasym, Clifford R. Shew, Sharon A. Johnstone, Euan C. Ramsay, Marcel B. Bally, and Andrew S. Janoff
Mol Cancer Ther 2006 5: 1854-1863 doi: 10.1158/1535-7163.MCT-06-0118 [Abstract] [Full Text] [PDF]  

Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells

Wei-Qun Ding, Bolin Liu, Joshua L. Vaught, Richard D. Palmiter, and Stuart E. Lind
Mol Cancer Ther 2006 5: 1864-1872 doi: 10.1158/1535-7163.MCT-06-0067 [Abstract] [Full Text] [PDF]  

Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway

Hongbo Hu, Cheng Jiang, Todd Schuster, Guang-Xun Li, Peter T. Daniel, and Junxuan Lü
Mol Cancer Ther 2006 5: 1873-1882 doi: 10.1158/1535-7163.MCT-06-0063 [Abstract] [Full Text] [PDF]  

Sequence-dependent inhibition of human colon cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 (Zactima), an inhibitor of VEGFR and EGFR tyrosine kinases

Teresa Troiani, Owen Lockerbie, Mark Morrow, Fortunato Ciardiello, and S. Gail Eckhardt
Mol Cancer Ther 2006 5: 1883-1894 doi: 10.1158/1535-7163.MCT-06-0055 [Abstract] [Full Text] [PDF]  

Research Article: Development:

Assessment of gefitinib- and CI-1040-mediated changes in epidermal growth factor receptor signaling in HuCCT-1 human cholangiocarcinoma by serial fine needle aspiration

Manuel Hidalgo, Maria Luz Amador, Antonio Jimeno, Heather Mezzadra, Pina Patel, Audrey Chan, Matthew E. Nielsen, Anirban Maitra, and Soner Altiok
Mol Cancer Ther 2006 5: 1895-1903 doi: 10.1158/1535-7163.MCT-05-0525 [Abstract] [Full Text] [PDF]  

Correction:

Article on rAAC-endostatin inhibiting NPC tumor growth and metastasis

Mol Cancer Ther 2006 5: 1904 doi: 10.1158/1535-7163.MCT-06-COR2 [Full Text] [PDF]  

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