Reviews:

Survivin, a cancer target with an emerging role in normal adult tissues

Seiji Fukuda and Louis M. Pelus
Mol Cancer Ther 2006 5: 1087-1098 doi: 10.1158/1535-7163.MCT-05-0375 [Abstract] [Full Text] [PDF]  

The role of neuropilins in cancer

Lee M. Ellis
Mol Cancer Ther 2006 5: 1099-1107 doi: 10.1158/1535-7163.MCT-05-0538 [Abstract] [Full Text] [PDF]  

Research Articles: Targets:

Connective tissue growth factor–specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer

Takuma Aikawa, Jason Gunn, Suzanne M. Spong, Stephen J. Klaus, and Murray Korc
Mol Cancer Ther 2006 5: 1108-1116 doi: 10.1158/1535-7163.MCT-05-0516 [Abstract] [Full Text] [PDF]  

RNA interference–mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor

Bhagavathi A. Narayanan, Narayanan K. Narayanan, Leland Davis, and Dominick Nargi
Mol Cancer Ther 2006 5: 1117-1125 doi: 10.1158/1535-7163.MCT-05-0520 [Abstract] [Full Text] [PDF]  

Genes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatin

Martina Olivero, Tina Ruggiero, Silvia Saviozzi, Andrea Rasola, Nadia Coltella, Stefania Crispi, Ferdinando Di Cunto, Raffaele Calogero, and Maria Flavia Di Renzo
Mol Cancer Ther 2006 5: 1126-1135 doi: 10.1158/1535-7163.MCT-06-0013 [Abstract] [Full Text] [PDF]  

Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases

Keiran S.M. Smalley, Nikolas K. Haass, Patricia A. Brafford, Mercedes Lioni, Keith T. Flaherty, and Meenhard Herlyn
Mol Cancer Ther 2006 5: 1136-1144 doi: 10.1158/1535-7163.MCT-06-0084 [Abstract] [Full Text] [PDF] Supplementary Figures, Smalley  

Silibinin inhibits UVB- and epidermal growth factor–induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-B in mouse epidermal JB6 cells

Rana P. Singh, Sivanandhan Dhanalakshmi, Sarumathi Mohan, Chapla Agarwal, and Rajesh Agarwal
Mol Cancer Ther 2006 5: 1145-1153 doi: 10.1158/1535-7163.MCT-05-0478 [Abstract] [Full Text] [PDF]  

Chemotherapy-induced epidermal growth factor receptor activation determines response to combined gefitinib/chemotherapy treatment in non–small cell lung cancer cells

Sandra Van Schaeybroeck, Joan Kyula, Donal M. Kelly, Anthi Karaiskou-McCaul, Susan A. Stokesberry, Eric Van Cutsem, Daniel B. Longley, and Patrick G. Johnston
Mol Cancer Ther 2006 5: 1154-1165 doi: 10.1158/1535-7163.MCT-05-0446 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics:

Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc

Matilde Parreño, Jose P. Vaqué, Isolda Casanova, Pilar Frade, M. Virtudes Céspedes, Miguel Angel Pavón, Antoni Molins, Mercedes Camacho, Luis Vila, Josep F. Nomdedeu, Ramon Mangues, and Javier León
Mol Cancer Ther 2006 5: 1166-1175 doi: 10.1158/1535-7163.MCT-05-0257 [Abstract] [Full Text] [PDF]  

Motexafin gadolinium modulates levels of phosphorylated Akt and synergizes with inhibitors of Akt phosphorylation

Jason Ramos, Mint Sirisawad, Richard Miller, and Louie Naumovski
Mol Cancer Ther 2006 5: 1176-1182 doi: 10.1158/1535-7163.MCT-05-0280 [Abstract] [Full Text] [PDF]  

Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer

Jeffrey M. Albert, Kwang Woon Kim, Carolyn Cao, and Bo Lu
Mol Cancer Ther 2006 5: 1183-1189 doi: 10.1158/1535-7163.MCT-05-0400 [Abstract] [Full Text] [PDF]  

Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells

Giovanni Mario Pitari, Tong Li, Ronnie I. Baksh, and Scott A. Waldman
Mol Cancer Ther 2006 5: 1190-1196 doi: 10.1158/1535-7163.MCT-05-0415 [Abstract] [Full Text] [PDF]  

Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT

Nivedita Sain, Bhavani Krishnan, Michael G. Ormerod, Assunta De Rienzo, Wai M. Liu, Stanley B. Kaye, Paul Workman, and Ann L. Jackman
Mol Cancer Ther 2006 5: 1197-1208 doi: 10.1158/1535-7163.MCT-05-0445 [Abstract] [Full Text] [PDF]  

Enhancement of the radiosensitivity of cervical cancer cells by overexpressing p73

Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Rebecca Ching-Yu Leung, Helen Ka-Wai Law, Tsin-Wah Leung, and Hextan Yuen-Sheung Ngan
Mol Cancer Ther 2006 5: 1209-1215 doi: 10.1158/1535-7163.MCT-05-0451 [Abstract] [Full Text] [PDF]  

Sequential combination of flavopiridol and docetaxel reduces the levels of X-linked inhibitor of apoptosis and AKT proteins and stimulates apoptosis in human LNCaP prostate cancer cells

Lourdes A. Gomez, Alicia de las Pozas, and Carlos Perez-Stable
Mol Cancer Ther 2006 5: 1216-1226 doi: 10.1158/1535-7163.MCT-05-0467 [Abstract] [Full Text] [PDF]  

Green tea extract and (–)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1 protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells

Qunzhou Zhang, Xudong Tang, QingYi Lu, ZuoFeng Zhang, Jianyu Rao, and Anh D. Le
Mol Cancer Ther 2006 5: 1227-1238 doi: 10.1158/1535-7163.MCT-05-0490 [Abstract] [Full Text] [PDF]  

DNA mismatch repair and p53 function are major determinants of the rate of development of cisplatin resistance

Xinjian Lin and Stephen B. Howell
Mol Cancer Ther 2006 5: 1239-1247 doi: 10.1158/1535-7163.MCT-05-0491 [Abstract] [Full Text] [PDF]  

Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275

Ilker Y. Eyüpoglu, Eric Hahnen, Christian Tränkle, Nicolai E. Savaskan, Florian A. Siebzehnrübl, Rolf Buslei, Dieter Lemke, Wolfgang Wick, Rudolf Fahlbusch, and Ingmar Blümcke
Mol Cancer Ther 2006 5: 1248-1255 doi: 10.1158/1535-7163.MCT-05-0533 [Abstract] [Full Text] [PDF]  

Identification of new biomarkers for clinical trials of Hsp90 inhibitors

Hong Zhang, Daun Chung, Yong-Ching Yang, Laura Neely, Steven Tsurumoto, Junhua Fan, Lin Zhang, Marco Biamonte, John Brekken, Karen Lundgren, and Francis Burrows
Mol Cancer Ther 2006 5: 1256-1264 doi: 10.1158/1535-7163.MCT-05-0537 [Abstract] [Full Text] [PDF]  

Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated–p53 activation

Manjinder Kaur, Rajesh Agarwal, and Chapla Agarwal
Mol Cancer Ther 2006 5: 1265-1274 doi: 10.1158/1535-7163.MCT-06-0014 [Abstract] [Full Text] [PDF]  

Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics

Leo E. Gerweck, Shashirekha Vijayappa, and Sergey Kozin
Mol Cancer Ther 2006 5: 1275-1279 doi: 10.1158/1535-7163.MCT-06-0024 [Abstract] [Full Text] [PDF]  

Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248

Olga Potapova, A. Douglas Laird, Michelle A. Nannini, Angela Barone, Guangmin Li, Katherine G. Moss, Julie M. Cherrington, and Dirk B. Mendel
Mol Cancer Ther 2006 5: 1280-1289 doi: 10.1158/1535-7163.MCT-03-0156 [Abstract] [Full Text] [PDF]  

Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus–mediated expression of human endostatin

Xiang-Ping Li, Christine Y.S. Li, Xiaohua Li, Yanqing Ding, Lally L.Y. Chan, Pai-Hao Yang, Gang Li, Xiong Liu, Jennifer S. Lin, Jide Wang, Mingliang He, Hsiang-fu Kung, Marie C. Lin, and Ying Peng
Mol Cancer Ther 2006 5: 1290-1298 doi: 10.1158/1535-7163.MCT-05-0348 [Abstract] [Full Text] [PDF]  

Pharmacologic inhibition of cyclin-dependent kinase 4/6 activity arrests proliferation in myoblasts and rhabdomyosarcoma-derived cells

Raya Saab, Jennifer L. Bills, Alexander P. Miceli, Colleen M. Anderson, Joseph D. Khoury, David W. Fry, Fariba Navid, Peter J. Houghton, and Stephen X. Skapek
Mol Cancer Ther 2006 5: 1299-1308 doi: 10.1158/1535-7163.MCT-05-0383 [Abstract] [Full Text] [PDF]  

CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo

Joseph J. Buggy, Z. Alexander Cao, Kathryn E. Bass, Erik Verner, Sriram Balasubramanian, Liang Liu, Brian E. Schultz, Peter R. Young, and Stacie A. Dalrymple
Mol Cancer Ther 2006 5: 1309-1317 doi: 10.1158/1535-7163.MCT-05-0442 [Abstract] [Full Text] [PDF]  

Aspirin reduces the outcome of anticancer therapy in Meth A–bearing mice through activation of AKT-glycogen synthase kinase signaling

Antonella di Palma, Giuseppe Matarese, Vincenza Leone, Tiziana Di Matola, Fabio Acquaviva, Angela Maria Acquaviva, and Paolo Ricchi
Mol Cancer Ther 2006 5: 1318-1324 doi: 10.1158/1535-7163.MCT-05-0473 [Abstract] [Full Text] [PDF]  

Detection of histone deacetylase inhibition by noninvasive magnetic resonance spectroscopy

Madhuri Sankaranarayanapillai, William P. Tong, David S. Maxwell, Ashutosh Pal, Jihai Pang, William G. Bornmann, Juri G. Gelovani, and Sabrina M. Ronen
Mol Cancer Ther 2006 5: 1325-1334 doi: 10.1158/1535-7163.MCT-05-0494 [Abstract] [Full Text] [PDF]  

Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins

Moammir H. Aziz, Minakshi Nihal, Vivian X. Fu, David F. Jarrard, and Nihal Ahmad
Mol Cancer Ther 2006 5: 1335-1341 doi: 10.1158/1535-7163.MCT-05-0526 [Abstract] [Full Text] [PDF]  

Activation of membrane androgen receptors potentiates the antiproliferative effects of paclitaxel on human prostate cancer cells

Marilena Kampa, Christina Kogia, Panayiotis A. Theodoropoulos, Ploutarchos Anezinis, Ioannis Charalampopoulos, Evangelia A. Papakonstanti, Efstathios N. Stathopoulos, Anastassia Hatzoglou, Christos Stournaras, Achille Gravanis, and Elias Castanas
Mol Cancer Ther 2006 5: 1342-1351 doi: 10.1158/1535-7163.MCT-05-0527 [Abstract] [Full Text] [PDF]  

A novel peroxisome proliferator–activated receptor ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells

Kiyoshi Yamaguchi, Seong-Ho Lee, Thomas E. Eling, and Seung Joon Baek
Mol Cancer Ther 2006 5: 1352-1361 doi: 10.1158/1535-7163.MCT-05-0528 [Abstract] [Full Text] [PDF]  

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPAR-dependent and PPAR-independent pathways

Sudhakar Chintharlapalli, Sabitha Papineni, and Stephen Safe
Mol Cancer Ther 2006 5: 1362-1370 doi: 10.1158/1535-7163.MCT-06-0002 [Abstract] [Full Text] [PDF]  

Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells

Jerzy Jankun, Ansari M. Aleem, Sylvia Malgorzewicz, Maria Szkudlarek, Maria I. Zavodszky, David L. DeWitt, Michael Feig, Steven H. Selman, and Ewa Skrzypczak-Jankun
Mol Cancer Ther 2006 5: 1371-1382 doi: 10.1158/1535-7163.MCT-06-0021 [Abstract] [Full Text] [PDF]  

Correction:

Article on bortezomib and breast cancer

Mol Cancer Ther 2006 5: 1383 doi: 10.1158/1535-7163.MCT-5-5-COR1 [Full Text] [PDF]  

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