Commentary:

Apoptosis and anthracycline cardiotoxicity

Andrew Thorburn and Arthur E. Frankel
Mol Cancer Ther 2006 5: 197-199 doi: 10.1158/1535-7163.MCT-06-CO1 [Full Text] [PDF]  

Review:

Sphingolipid targets in cancer therapy

David E. Modrak, David V. Gold, and David M. Goldenberg
Mol Cancer Ther 2006 5: 200-208 doi: 10.1158/1535-7163.MCT-05-0420 [Abstract] [Full Text] [PDF]  

Articles:

Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment

Benjamin J. Friedmann, Martyn Caplin, Boris Savic, Tahir Shah, Christopher J. Lord, Alan Ashworth, John A. Hartley, and Daniel Hochhauser
Mol Cancer Ther 2006 5: 209-218 doi: 10.1158/1535-7163.MCT-05-0239 [Abstract] [Full Text] [PDF]  

Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function

Cecile Rouleau, Andre Roy, Thia St. Martin, Michael R. Dufault, Paula Boutin, Dapei Liu, Mindy Zhang, Kristin Puorro-Radzwill, Lori Rulli, Dave Reczek, Rebecca Bagley, Ann Byrne, William Weber, Bruce Roberts, Katherine Klinger, William Brondyk, Mariana Nacht, Steve Madden, Robert Burrier, Srinivas Shankara, and Beverly A. Teicher
Mol Cancer Ther 2006 5: 219-229 doi: 10.1158/1535-7163.MCT-05-0289 [Abstract] [Full Text] [PDF]  

Altered localization of a coactivator sensitizes breast cancer cells to tumor necrosis factor–induced apoptosis

Suresh K. Rayala, Joseph Mascarenhas, Ratna K. Vadlamudi, and Rakesh Kumar
Mol Cancer Ther 2006 5: 230-237 doi: 10.1158/1535-7163.MCT-05-0276 [Abstract] [Full Text] [PDF]  

Lipid rafts remodeling in estrogen receptor–negative breast cancer is reversed by histone deacetylase inhibitor

Anna Ostapkowicz, Kunihiro Inai, Leia Smith, Silvia Kreda, and Jozef Spychala
Mol Cancer Ther 2006 5: 238-245 doi: 10.1158/1535-7163.MCT-05-0226 [Abstract] [Full Text] [PDF]  

Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells

Yue Wu, Ke Zu, Mary Ann Warren, Paul K. Wallace, and Clement Ip
Mol Cancer Ther 2006 5: 246-252 doi: 10.1158/1535-7163.MCT-05-0376 [Abstract] [Full Text] [PDF]  

14-3-3, a p53 regulator, suppresses tumor growth of nasopharyngeal carcinoma

Huiling Yang, Ruiying Zhao, and Mong-Hong Lee
Mol Cancer Ther 2006 5: 253-260 doi: 10.1158/1535-7163.MCT-05-0395 [Abstract] [Full Text] [PDF]  

Tumor necrosis factor receptor deficiency exacerbated Adriamycin-induced cardiomyocytes apoptosis: an insight into the Fas connection

Yu-Chin Lien, Shu-Mei Lin, Ramaneeya Nithipongvanitch, Terry D. Oberley, Teresa Noel, Qing Zhao, Chotiros Daosukho, and Daret K. St. Clair
Mol Cancer Ther 2006 5: 261-269 doi: 10.1158/1535-7163.MCT-05-0390 [Abstract] [Full Text] [PDF]  

Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of ß-tubulin (Asp²⁶Glu) and less stable microtubules

Malathi Hari, Frank Loganzo, Tami Annable, Xingzhi Tan, Sylvia Musto, Daniel B. Morilla, James H. Nettles, James P. Snyder, and Lee M. Greenberger
Mol Cancer Ther 2006 5: 270-278 doi: 10.1158/1535-7163.MCT-05-0190 [Abstract] [Full Text] [PDF] Supplementary Data  

Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer

Naijie Jing, Qiqing Zhu, Ping Yuan, Yidong Li, Li Mao, and David J. Tweardy
Mol Cancer Ther 2006 5: 279-286 doi: 10.1158/1535-7163.MCT-05-0302 [Abstract] [Full Text] [PDF]  

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

Christophe Marchand, Smitha Antony, Kurt W. Kohn, Mark Cushman, Alexandra Ioanoviciu, Bart L. Staker, Alex B. Burgin, Lance Stewart, and Yves Pommier
Mol Cancer Ther 2006 5: 287-295 doi: 10.1158/1535-7163.MCT-05-0456 [Abstract] [Full Text] [PDF]  

Berberine, a natural product, induces G₁-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells

Sudheer K. Mantena, Som D. Sharma, and Santosh K. Katiyar
Mol Cancer Ther 2006 5: 296-308 doi: 10.1158/1535-7163.MCT-05-0448 [Abstract] [Full Text] [PDF]  

RRR--Tocopherol succinate down-regulates oncogenic Ras signaling

Sreenivasa Donapaty, Somaja Louis, Elizabeth Horvath, Jiang Kun, Said M. Sebti, and Mokenge P. Malafa
Mol Cancer Ther 2006 5: 309-316 doi: 10.1158/1535-7163.MCT-05-0330 [Abstract] [Full Text] [PDF]  

Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells

Marina Konopleva, Weiguo Zhang, Yue-Xi Shi, Teresa McQueen, Twee Tsao, Maen Abdelrahim, Mark F. Munsell, Mary Johansen, Dihua Yu, Timothy Madden, Stephen H. Safe, Mien-Chie Hung, and Michael Andreeff
Mol Cancer Ther 2006 5: 317-328 doi: 10.1158/1535-7163.MCT-05-0350 [Abstract] [Full Text] [PDF]  

Cyclooxygenase inhibitors in urinary bladder cancer: in vitro and in vivo effects

Sulma I. Mohammed, Deepika Dhawan, Shaji Abraham, Paul W. Snyder, David J. Waters, Bruce A. Craig, Ming Lu, Lan Wu, Rong Zheng, Jane Stewart, and Deborah W. Knapp
Mol Cancer Ther 2006 5: 329-336 doi: 10.1158/1535-7163.MCT-05-0117 [Abstract] [Full Text] [PDF]  

Circadian pharmacology of L-alanosine (SDX-102) in mice

Xiao-Mei Li, Sarath Kanekal, Delphine Crépin, Catherine Guettier, Jennifer Carrière, Gary Elliott, and Francis Lévi
Mol Cancer Ther 2006 5: 337-346 doi: 10.1158/1535-7163.MCT-05-0332 [Abstract] [Full Text] [PDF]  

Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor–positive breast carcinoma models

Kenneth R. LaMontagne, Jeannene Butler, Deborah J. Marshall, Jennifer Tullai, Ze'ev Gechtman, Chassidy Hall, Alan Meshaw, and Francis X. Farrell
Mol Cancer Ther 2006 5: 347-355 doi: 10.1158/1535-7163.MCT-05-0203 [Abstract] [Full Text] [PDF]  

Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity

Matthew E. Hardee, Zahid N. Rabbani, Murat O. Arcasoy, John P. Kirkpatrick, Zeljko Vujaskovic, Mark W. Dewhirst, and Kimberly L. Blackwell
Mol Cancer Ther 2006 5: 356-361 doi: 10.1158/1535-7163.MCT-05-0196 [Abstract] [Full Text] [PDF]  

Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery

Yong Wang, He Wang, Chuan-Yuan Li, and Fan Yuan
Mol Cancer Ther 2006 5: 362-366 doi: 10.1158/1535-7163.MCT-05-0266 [Abstract] [Full Text] [PDF]  

An oncolytic adenovirus expressing soluble transforming growth factor-ß type II receptor for targeting breast cancer: in vitro evaluation

Zhen-Guo Wang, Wenli Zhao, Murali Ramachandra, and Prem Seth
Mol Cancer Ther 2006 5: 367-373 doi: 10.1158/1535-7163.MCT-05-0125 [Abstract] [Full Text] [PDF]  

Restriction of adenoviral replication to the transcriptional intersection of two different promoters for colorectal and pancreatic cancer treatment

Dennis Hoffmann and Oliver Wildner
Mol Cancer Ther 2006 5: 374-381 doi: 10.1158/1535-7163.MCT-05-0374 [Abstract] [Full Text] [PDF]  

Expression and regulation of tumor necrosis factor in normal and malignant ovarian epithelium

Peter W. Szlosarek, Matthew J. Grimshaw, Hagen Kulbe, Julia L. Wilson, George D. Wilbanks, Frances Burke, and Frances R. Balkwill
Mol Cancer Ther 2006 5: 382-390 doi: 10.1158/1535-7163.MCT-05-0303 [Abstract] [Full Text] [PDF]  

The cardenolide UNBS1450 is able to deactivate nuclear factor B–mediated cytoprotective effects in human non–small cell lung cancer cells

Tatjana Mijatovic, Anne Op De Beeck, Eric Van Quaquebeke, Janique Dewelle, Francis Darro, Yvan de Launoit, and Robert Kiss
Mol Cancer Ther 2006 5: 391-399 doi: 10.1158/1535-7163.MCT-05-0367 [Abstract] [Full Text] [PDF]  

c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-ß-D-arabinofuranosylcytosine–induced apoptosis in wild-type and p53-null colorectal cancer cells

Jaideep V. Thottassery, Louise Westbrook, Hitoshi Someya, and William B. Parker
Mol Cancer Ther 2006 5: 400-410 doi: 10.1158/1535-7163.MCT-05-0409 [Abstract] [Full Text] [PDF]  

Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2

Carolyn Cao, Eric T. Shinohara, Ty K. Subhawong, Ling Geng, Kwang Woon Kim, Jeffrey M. Albert, Dennis E. Hallahan, and Bo Lu
Mol Cancer Ther 2006 5: 411-417 doi: 10.1158/1535-7163.MCT-05-0356 [Abstract] [Full Text] [PDF]  

Enhancement of UVB radiation–mediated apoptosis by sanguinarine in HaCaT human immortalized keratinocytes

Shannon Reagan-Shaw, Jorien Breur, and Nihal Ahmad
Mol Cancer Ther 2006 5: 418-429 doi: 10.1158/1535-7163.MCT-05-0250 [Abstract] [Full Text] [PDF]  

Rosiglitazone suppresses human lung carcinoma cell growth through PPAR-dependent and PPAR-independent signal pathways

ShouWei Han and Jesse Roman
Mol Cancer Ther 2006 5: 430-437 doi: 10.1158/1535-7163.MCT-05-0347 [Abstract] [Full Text] [PDF]  

The inverse relationship between reduced folate carrier function and Pemetrexed activity in a human colon cancer cell line

Shrikanta Chattopadhyay, Rongbao Zhao, Sergey A. Krupenko, Natalia Krupenko, and I. David Goldman
Mol Cancer Ther 2006 5: 438-449 doi: 10.1158/1535-7163.MCT-05-0243 [Abstract] [Full Text] [PDF]  

A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities

Pui-Kai Li, Bulbul Pandit, Dan L. Sackett, Zhigen Hu, Jennifer Zink, Jiandong Zhi, Dena Freeman, Robert W. Robey, Karl Werbovetz, Andrew Lewis, and Chenglong Li
Mol Cancer Ther 2006 5: 450-456 doi: 10.1158/1535-7163.MCT-05-0254 [Abstract] [Full Text] [PDF]  

IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells

Naoko Takebe, Xiangfei Cheng, Tamer E. Fandy, Rakesh K. Srivastava, Suhlan Wu, Sharmila Shankar, Kenneth Bauer, John Shaughnessy, and Guido Tricot
Mol Cancer Ther 2006 5: 457-466 doi: 10.1158/1535-7163.MCT-05-0340 [Abstract] [Full Text] [PDF]  

Angiostatic activity of DNA methyltransferase inhibitors

Debby M.E.I. Hellebrekers, Kam-Wing Jair, Emmanuelle Viré, Sayaka Eguchi, Nicole T.H. Hoebers, Mario F. Fraga, Manel Esteller, François Fuks, Stephen B. Baylin, Manon van Engeland, and Arjan W. Griffioen
Mol Cancer Ther 2006 5: 467-475 doi: 10.1158/1535-7163.MCT-05-0417 [Abstract] [Full Text] [PDF]  

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