Spotlight on Molecular Profiling:

Spotlight on molecular profiling: "Integromic" analysis of the NCI-60 cancer cell lines

John N. Weinstein
Mol Cancer Ther 2006 5: 2601-2605Published Online First November 6, 2006. doi: 10.1158/1535-7163.MCT-06-0640 [Full Text] [PDF]  

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set

Ogechi N. Ikediobi, Helen Davies, Graham Bignell, Sarah Edkins, Claire Stevens, Sarah O'Meara, Thomas Santarius, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathan Hinton, Chris Hunter, Andy Jenkinson, David Jones, Vivienne Kosmidou, Richard Lugg, Andrew Menzies, Tatiana Mironenko, Adrian Parker, Janet Perry, Keiran Raine, David Richardson, Rebecca Shepherd, Alex Small, Raffaella Smith, Helen Solomon, Philip Stephens, Jon Teague, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, William Reinhold, John N. Weinstein, Michael R. Stratton, P. Andrew Futreal, and Richard Wooster
Mol Cancer Ther 2006 5: 2606-2612Published Online First November 6, 2006. doi: 10.1158/1535-7163.MCT-06-0433 [Abstract] [Full Text] [PDF] Supplementary Material  

Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells

Philip L. Lorenzi, William C. Reinhold, Martina Rudelius, Michele Gunsior, Uma Shankavaram, Kimberly J. Bussey, Uwe Scherf, Gabriel S. Eichler, Scott E. Martin, Koei Chin, Joe W. Gray, Elise C. Kohn, Ivan D. Horak, Daniel D. Von Hoff, Mark Raffeld, Paul K. Goldsmith, Natasha J. Caplen, and John N. Weinstein
Mol Cancer Ther 2006 5: 2613-2623Published Online First November 6, 2006. doi: 10.1158/1535-7163.MCT-06-0447 [Abstract] [Full Text] [PDF]  

Drug Development Series: Review:

How molecular imaging is speeding up antiangiogenic drug development

Weibo Cai, Jianghong Rao, Sanjiv S. Gambhir, and Xiaoyuan Chen
Mol Cancer Ther 2006 5: 2624-2633 doi: 10.1158/1535-7163.MCT-06-0395 [Abstract] [Full Text] [PDF]  

Research Articles: Therapeutics, Targets, and Development:

A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model

Hiroaki Ohno, Kazuo Kubo, Hideko Murooka, Yoshiko Kobayashi, Tsuyoshi Nishitoba, Masabumi Shibuya, Toshiyuki Yoneda, and Toshiyuki Isoe
Mol Cancer Ther 2006 5: 2634-2643 doi: 10.1158/1535-7163.MCT-05-0313 [Abstract] [Full Text] [PDF]  

In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

Wanda DePinto, Xin-Jie Chu, Xuefeng Yin, Melissa Smith, Kathryn Packman, Petra Goelzer, Allen Lovey, Yingsi Chen, Hong Qian, Rachid Hamid, Qing Xiang, Christian Tovar, Roger Blain, Tom Nevins, Brian Higgins, Leopoldo Luistro, Kenneth Kolinsky, Bernardo Felix, Sazzad Hussain, and David Heimbrook
Mol Cancer Ther 2006 5: 2644-2658 doi: 10.1158/1535-7163.MCT-06-0355 [Abstract] [Full Text] [PDF]  

Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation

Kwang Woon Kim, Robert W. Mutter, Carolyn Cao, Jeffrey M. Albert, Eric T. Shinohara, Konjeti R. Sekhar, and Bo Lu
Mol Cancer Ther 2006 5: 2659-2665 doi: 10.1158/1535-7163.MCT-06-0261 [Abstract] [Full Text] [PDF]  

Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt–dependent matrix metalloproteinase-9 expression

Sang-Oh Yoon, Sejeong Shin, Ho-Jae Lee, Hyo-Kon Chun, and An-Sik Chung
Mol Cancer Ther 2006 5: 2666-2675 doi: 10.1158/1535-7163.MCT-06-0321 [Abstract] [Full Text] [PDF]  

Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non–small-cell lung, pancreatic, colon, and breast tumors

Elizabeth Buck, Alexandra Eyzaguirre, Eric Brown, Filippo Petti, Siobhan McCormack, John D. Haley, Kenneth K. Iwata, Neil W. Gibson, and Graeme Griffin
Mol Cancer Ther 2006 5: 2676-2684 doi: 10.1158/1535-7163.MCT-06-0166 [Abstract] [Full Text] [PDF]  

Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor–independent urokinase-type plasminogen activator inhibition

Seung-Hyun Oh, Ok-Hee Lee, Claudia P. Schroeder, Yun W. Oh, Shi Ke, Hee-Jae Cha, Rang-Woon Park, Amir Onn, Roy S. Herbst, Chun Li, and Ho-Young Lee
Mol Cancer Ther 2006 5: 2685-2695 doi: 10.1158/1535-7163.MCT-06-0142 [Abstract] [Full Text] [PDF]  

Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model

Maher N. Younes, Young Wook Park, Yasemin Dakak Yazici, Meirong Gu, Alfredo A. Santillan, Xiaolin Nong, Seungwon Kim, Samar A. Jasser, Adel K. El-Naggar, and Jeffrey N. Myers
Mol Cancer Ther 2006 5: 2696-2705 doi: 10.1158/1535-7163.MCT-05-0228 [Abstract] [Full Text] [PDF]  

Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs

Emilie Roudier, Oras Mistafa, and Ulla Stenius
Mol Cancer Ther 2006 5: 2706-2715 doi: 10.1158/1535-7163.MCT-06-0352 [Abstract] [Full Text] [PDF]  

Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells

Fabio Cianchi, Camillo Cortesini, Lucia Magnelli, Elena Fanti, Laura Papucci, Nicola Schiavone, Luca Messerini, Alfredo Vannacci, Sergio Capaccioli, Federico Perna, Matteo Lulli, Valentina Fabbroni, Giuliano Perigli, Paolo Bechi, and Emanuela Masini
Mol Cancer Ther 2006 5: 2716-2726 doi: 10.1158/1535-7163.MCT-06-0318 [Abstract] [Full Text] [PDF]  

Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2A

Kathy Bonness, Ileana V. Aragon, Beth Rutland, Solomon Ofori-Acquah, Nicholas M. Dean, and Richard E. Honkanen
Mol Cancer Ther 2006 5: 2727-2736 doi: 10.1158/1535-7163.MCT-06-0273 [Abstract] [Full Text] [PDF]  

Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites

Tae-Jin Lee, Eun Mi Jung, Jung Tae Lee, Shin Kim, Jong-Wook Park, Kyeong Sook Choi, and Taeg Kyu Kwon
Mol Cancer Ther 2006 5: 2737-2746 doi: 10.1158/1535-7163.MCT-06-0426 [Abstract] [Full Text] [PDF]  

Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model

KM Wahidur Rahman, Fazlul H. Sarkar, Sanjeev Banerjee, Zhiwei Wang, Dezhong J. Liao, Xin Hong, and Nurul H. Sarkar
Mol Cancer Ther 2006 5: 2747-2756 doi: 10.1158/1535-7163.MCT-06-0221 [Abstract] [Full Text] [PDF]  

The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G₂ arrest and cytotoxicity

Olga K. Mirzoeva, Tomohiro Kawaguchi, and Russell O. Pieper
Mol Cancer Ther 2006 5: 2757-2766 doi: 10.1158/1535-7163.MCT-06-0183 [Abstract] [Full Text] [PDF]  

Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells

Sean C. Dowdy, Shujuan Jiang, X. Clare Zhou, Xiaonan Hou, Fan Jin, Karl C. Podratz, and Shi-Wen Jiang
Mol Cancer Ther 2006 5: 2767-2776 doi: 10.1158/1535-7163.MCT-06-0209 [Abstract] [Full Text] [PDF]  

Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors

Laura R. Saunders and Eric Verdin
Mol Cancer Ther 2006 5: 2777-2785 doi: 10.1158/1535-7163.MCT-06-0298 [Abstract] [Full Text] [PDF]  

Potentiation of radiation sensitivity in breast tumor cells by the vitamin D₃ analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery

Gerald DeMasters, Xu Di, Irene Newsham, Robert Shiu, and David A. Gewirtz
Mol Cancer Ther 2006 5: 2786-2797 doi: 10.1158/1535-7163.MCT-06-0316 [Abstract] [Full Text] [PDF]  

Tumor localization and antitumor efficacy of novel sapphyrin compounds

Louie Naumovski, Mint Sirisawad, Philip Lecane, Jun Chen, Jason Ramos, Zhong Wang, Cecilia Cortez, Darren Magda, Patti Thiemann, Garry Boswell, Dale Miles, Dong Gyu Cho, Jonathan L. Sessler, and Richard Miller
Mol Cancer Ther 2006 5: 2798-2805 doi: 10.1158/1535-7163.MCT-06-0246 [Abstract] [Full Text] [PDF]  

QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D₃, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells

Sujatha Sundaram, Matthew J. Beckman, Amandeep Bajwa, Jeffrey Wei, Kathleen M. Smith, Gary H. Posner, and David A. Gewirtz
Mol Cancer Ther 2006 5: 2806-2814 doi: 10.1158/1535-7163.MCT-06-0092 [Abstract] [Full Text] [PDF]  

Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL–expressing cells

Patrick Yoon, Nick Giafis, Jessica Smith, Heather Mears, Efstratios Katsoulidis, Antonella Sassano, Jessica Altman, Amanda J. Redig, Martin S. Tallman, and Leonidas C. Platanias
Mol Cancer Ther 2006 5: 2815-2823 doi: 10.1158/1535-7163.MCT-06-0263 [Abstract] [Full Text] [PDF]  

Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine

Marie-Anne Estève, Manon Carré, Véronique Bourgarel-Rey, Anna Kruczynski, Giuseppina Raspaglio, Cristiano Ferlini, and Diane Braguer
Mol Cancer Ther 2006 5: 2824-2833 doi: 10.1158/1535-7163.MCT-06-0277 [Abstract] [Full Text] [PDF]  

Gallium-induced cell death in lymphoma: role of transferrin receptor cycling, involvement of Bax and the mitochondria, and effects of proteasome inhibition

Christopher R. Chitambar, Janine P. Wereley, and Shigemi Matsuyama
Mol Cancer Ther 2006 5: 2834-2843 doi: 10.1158/1535-7163.MCT-06-0285 [Abstract] [Full Text] [PDF]  

Pretherapy nuclear factor-B status, chemoradiation resistance, and metastatic progression in esophageal carcinoma

Julie G. Izzo, Arlene M. Correa, Tsung-Teh Wu, Usha Malhotra, Clifford K.S. Chao, Rajyalakshmi Luthra, Joe Ensor, Alexander Dekovich, Zhongxing Liao, Walter N. Hittelman, Bharat B. Aggarwal, and Jaffer A. Ajani
Mol Cancer Ther 2006 5: 2844-2850 doi: 10.1158/1535-7163.MCT-06-0351 [Abstract] [Full Text] [PDF]  

Increase in Mrp1 expression and 4-hydroxy-2-nonenal adduction in heart tissue of Adriamycin-treated C57BL/6 mice

Paiboon Jungsuwadee, Marsha P. Cole, Rukhsana Sultana, Gurujaj Joshi, Jitbanjong Tangpong, D. Allan Butterfield, Daret K. St. Clair, and Mary Vore
Mol Cancer Ther 2006 5: 2851-2860 doi: 10.1158/1535-7163.MCT-06-0297 [Abstract] [Full Text] [PDF]  

Targeting the active ß-catenin pathway to treat cancer cells

Hadas Dvory-Sobol, Eyal Sagiv, Diana Kazanov, Avri Ben-Ze'ev, and Nadir Arber
Mol Cancer Ther 2006 5: 2861-2871 doi: 10.1158/1535-7163.MCT-06-0122 [Abstract] [Full Text] [PDF]  

Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-B activation

Pengcheng Bu, Lizeng Gao, Jie Zhuang, Jing Feng, Dongling Yang, and Xiyun Yan
Mol Cancer Ther 2006 5: 2872-2878 doi: 10.1158/1535-7163.MCT-06-0260 [Abstract] [Full Text] [PDF]  

Absorption and subcellular localization of lycopene in human prostate cancer cells

Ang Liu, Natasa Pajkovic, Yan Pang, Dongwei Zhu, Barbara Calamini, Andrew L. Mesecar, and Richard B. van Breemen
Mol Cancer Ther 2006 5: 2879-2885 doi: 10.1158/1535-7163.MCT-06-0373 [Abstract] [Full Text] [PDF]  

Synthesis and biological properties of bioreductively targeted nitrothienyl prodrugs of combretastatin A-4

Peter Thomson, Matthew A. Naylor, Steven A. Everett, Michael R.L. Stratford, Gemma Lewis, Sally Hill, Kantilal B. Patel, Peter Wardman, and Peter D. Davis
Mol Cancer Ther 2006 5: 2886-2894 doi: 10.1158/1535-7163.MCT-06-0429 [Abstract] [Full Text] [PDF]  

Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance

Alain Morel, Michele Boisdron-Celle, Luc Fey, Patrick Soulie, Marie Claire Craipeau, Sori Traore, and Erick Gamelin
Mol Cancer Ther 2006 5: 2895-2904 doi: 10.1158/1535-7163.MCT-06-0327 [Abstract] [Full Text] [PDF]  

Frequent overexpression of aurora B kinase, a novel drug target, in non–small cell lung carcinoma patients

Barbara Vischioni, Joost J. Oudejans, Wim Vos, Jose A. Rodriguez, and Giuseppe Giaccone
Mol Cancer Ther 2006 5: 2905-2913 doi: 10.1158/1535-7163.MCT-06-0301 [Abstract] [Full Text] [PDF]  

Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer

Therese Sørlie, Charles M. Perou, Cheng Fan, Stephanie Geisler, Turid Aas, Andrew Nobel, Gun Anker, Lars A. Akslen, David Botstein, Anne-Lise Børresen-Dale, and Per Eystein Lønning
Mol Cancer Ther 2006 5: 2914-2918 doi: 10.1158/1535-7163.MCT-06-0126 [Abstract] [Full Text] [PDF] Supplementary Material  

C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer

Elizabeth E. Evans, Alicia D. Henn, Alan Jonason, Mark J. Paris, Linda M. Schiffhauer, Melinda A. Borrello, Ernest S. Smith, Deepak M. Sahasrabudhe, and Maurice Zauderer
Mol Cancer Ther 2006 5: 2919-2930 doi: 10.1158/1535-7163.MCT-06-0389 [Abstract] [Full Text] [PDF]  

Benzyl isothiocyanate–induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak

Dong Xiao, Victor Vogel, and Shivendra V. Singh
Mol Cancer Ther 2006 5: 2931-2945 doi: 10.1158/1535-7163.MCT-06-0396 [Abstract] [Full Text] [PDF]  

Identification of SK3 channel as a new mediator of breast cancer cell migration

Marie Potier, Virginie Joulin, Sébastien Roger, Pierre Besson, Marie-Lise Jourdan, Jean-Yves LeGuennec, Philippe Bougnoux, and Christophe Vandier
Mol Cancer Ther 2006 5: 2946-2953 doi: 10.1158/1535-7163.MCT-06-0194 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Therapeutic potential of epidermal growth factor receptor–related protein

Jill L. Reiter, Nita J. Maihle, and Gail M. Clinton
Mol Cancer Ther 2006 5: 2954 doi: 10.1158/1535-7163.MCT-05-0404 [Full Text] [PDF]  

Therapeutic potential of epidermal growth factor receptor–related protein

Adhip P.N. Majumdar and Arun K. Rishi
Mol Cancer Ther 2006 5: 2955 doi: 10.1158/1535-7163.MCT-06-0120 [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.