In vivo effects of p53p-Ant administered by convection-enhanced delivery. Male Fisher rats had control peptide (p53p and Ant) or p53p-Ant infused over a 6-h period by a convection-enhanced delivery system and repeated once, separated by a hiatus of 12 h. Animals were monitored for adverse symptoms such as ataxia or seizure and sacrificed 12 h after the second infusion of peptide (total 36 h). Brains were immediately fixed, sectioned, and stained for presence of apoptosis using the TUNEL method. Top, morphological pictures; bottom, percentage of apoptotic cells. For details, see article by Senatus et al. in this issue.