Articles:

Murine double minute 2 as a therapeutic target for radiation sensitization of lung cancer

Carolyn Cao, Eric T. Shinohara, Kenneth J. Niermann, Edwin F. Donnelly, Xinping Chen, Dennis E. Hallahan, and Bo Lu
Mol Cancer Ther 2005 4: 1137-1145. [Abstract] [Full Text] [PDF]  

Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer

Maher N. Younes, Seungwon Kim, Orhan G. Yigitbasi, Mahitosh Mandal, Samar A. Jasser, Yasemin Dakak Yazici, Bradley A. Schiff, Adel El-Naggar, Benjamin N. Bekele, Gordon B. Mills, and Jeffrey N. Myers
Mol Cancer Ther 2005 4: 1146-1156. [Abstract] [Full Text] [PDF]  

Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo

Takahiro Nonaka, Kunika Nishibashi, Yoshifumi Itoh, Ikuo Yana, and Motoharu Seiki
Mol Cancer Ther 2005 4: 1157-1166. [Abstract] [Full Text] [PDF]  

T315I-mutated Bcr-Abl in chronic myeloid leukemia and imatinib: insights from a computational study

Sabrina Pricl, Maurizio Fermeglia, Marco Ferrone, and Elena Tamborini
Mol Cancer Ther 2005 4: 1167-1174. [Abstract] [Full Text] [PDF]  

Hedamycin, a DNA alkylator, induces H2AX and chromosome aberrations: Involvement of phosphatidylinositol 3-kinase–related kinases and DNA replication fork movement

Lan Chun Tu, Sei ichi Matsui, and Terry A. Beerman
Mol Cancer Ther 2005 4: 1175-1185. [Abstract] [Full Text] [PDF]  

Temporal quantitation of mutant Kit tyrosine kinase signaling attenuated by a novel thiophene kinase inhibitor OSI-930

Filippo Petti, April Thelemann, Jen Kahler, Siobhan McCormack, Linda Castaldo, Tony Hunt, Lydia Nuwaysir, Lynn Zeiske, Herbert Haack, Laura Sullivan, Andrew Garton, and John D. Haley
Mol Cancer Ther 2005 4: 1186-1197. [Abstract] [Full Text] [PDF]  

Validation of in vivo pharmacodynamic activity of a novel PDGF receptor tyrosine kinase inhibitor using immunohistochemistry and quantitative image analysis

Michael R. D'Andrea, Jay M. Mei, Robert W. Tuman, Robert A. Galemmo, and Dana L. Johnson
Mol Cancer Ther 2005 4: 1198-1204. [Abstract] [Full Text] [PDF]  

The immunocytokine scFv23/TNF sensitizes HER-2/neu–overexpressing SKBR-3 cells to tumor necrosis factor (TNF) via up-regulation of TNF receptor-1

Mi-Ae Lyu and Michael G. Rosenblum
Mol Cancer Ther 2005 4: 1205-1213. [Abstract] [Full Text] [PDF]  

Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti–IGF-IR antibody

Yan Wang, Judith Hailey, Denise Williams, Yaolin Wang, Philip Lipari, Michael Malkowski, Xiaoying Wang, Lei Xie, Guanghua Li, Deba Saha, Wai Lam W. Ling, Susan Cannon-Carlson, Robert Greenberg, Robert A. Ramos, Robert Shields, Leonard Presta, Peter Brams, W. Robert Bishop, and Jonathan A. Pachter
Mol Cancer Ther 2005 4: 1214-1221. [Abstract] [Full Text] [PDF]  

Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines

Pilar García-Morales, Angeles Gómez-Martínez, Alfredo Carrato, Isabel Martínez-Lacaci, Víctor M. Barberá, José L. Soto, Estefanía Carrasco-García, María P. Menéndez-Gutierrez, María D. Castro-Galache, José A. Ferragut, and Miguel Saceda
Mol Cancer Ther 2005 4: 1222-1230. [Abstract] [Full Text] [PDF]  

Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death

Ragnhild V. Nome, Åse Bratland, Gunhild Harman, Øystein Fodstad, Yvonne Andersson, and Anne Hansen Ree
Mol Cancer Ther 2005 4: 1231-1238. [Abstract] [Full Text] [PDF]  

Selenium disrupts estrogen receptor signaling and potentiates tamoxifen antagonism in endometrial cancer cells and tamoxifen-resistant breast cancer cells

Yatrik M. Shah, Mariam Al-Dhaheri, Yan Dong, Clement Ip, Frank E. Jones, and Brian G. Rowan
Mol Cancer Ther 2005 4: 1239-1249. [Abstract] [Full Text] [PDF]  

Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells

Li Tang and Yuesheng Zhang
Mol Cancer Ther 2005 4: 1250-1259. [Abstract] [Full Text] [PDF]  

The antiproliferative agent MLN944 preferentially inhibits transcription

Sarah A. Byers, Blanca Schafer, Darshan S. Sappal, Jeffery Brown, and David H. Price
Mol Cancer Ther 2005 4: 1260-1267. [Abstract] [Full Text] [PDF]  

Increased expression of the large subunit of ribonucleotide reductase is involved in resistance to gemcitabine in human mammary adenocarcinoma cells

Lars Petter Jordheim, Olivier Guittet, Michel Lepoivre, Carlos M. Galmarini, and Charles Dumontet
Mol Cancer Ther 2005 4: 1268-1276. [Abstract] [Full Text] [PDF]  

Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria

Chin-Chung Wu, Mei-Ling Chan, Wen-Ying Chen, Ching-Yi Tsai, Fang-Rong Chang, and Yang-Chang Wu
Mol Cancer Ther 2005 4: 1277-1285. [Abstract] [Full Text] [PDF]  

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