Minireview:

Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology

Dan A. Laheru, Drew M. Pardoll, and Elizabeth M. Jaffee
Mol Cancer Ther 2005 4: 1645-1652 doi: 10.1158/1535-7163.MCT-05-0151 [Abstract] [Full Text] [PDF]  

PRL phosphatases as potential molecular targets in cancer

Bret J. Stephens, Haiyong Han, Vijay Gokhale, and Daniel D. Von Hoff
Mol Cancer Ther 2005 4: 1653-1661 doi: 10.1158/1535-7163.MCT-05-0248 [Abstract] [Full Text] [PDF]  

Articles:

Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model

Romyla Ilagan, Liquin Joann Zhang, Jill Pottratz, Kim Le, Sussan Salas, Meera Iyer, Lily Wu, Sanjiv S. Gambhir, and Michael Carey
Mol Cancer Ther 2005 4: 1662-1669 doi: 10.1158/1535-7163.MCT-05-0197 [Abstract] [Full Text] [PDF]  

Biological and molecular properties of a new _vß₃/_vß₅ integrin antagonist

Laura Belvisi, Teresa Riccioni, Marcella Marcellini, Loredana Vesci, Ilaria Chiarucci, Daniela Efrati, Donatella Potenza, Carlo Scolastico, Leonardo Manzoni, Katia Lombardo, M. Antonietta Stasi, Augusto Orlandi, Alessandro Ciucci, Beatrice Nico, Domenico Ribatti, Giuseppe Giannini, Marco Presta, Paolo Carminati, and Claudio Pisano
Mol Cancer Ther 2005 4: 1670-1680 doi: 10.1158/1535-7163.MCT-05-0120 [Abstract] [Full Text] [PDF]  

Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma

Dimpy Koul, Ruijun Shen, Sherry Bergh, Yiling Lu, John F. de Groot, Ta Jen Liu, Gordon B. Mills, and W.K. Alfred Yung
Mol Cancer Ther 2005 4: 1681-1688 doi: 10.1158/1535-7163.MCT-05-0258 [Abstract] [Full Text] [PDF]  

A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells

Kazuki Yamanaka, Palma Rocchi, Hideaki Miyake, Ladan Fazli, Bob Vessella, Uwe Zangemeister-Wittke, and Martin E. Gleave
Mol Cancer Ther 2005 4: 1689-1698 doi: 10.1158/1535-7163.MCT-05-0064 [Abstract] [Full Text] [PDF]  

Antiproliferative activity of angiotensin II receptor blocker through cross-talk between stromal and epithelial prostate cancer cells

Hiroji Uemura, Hitoshi Ishiguro, Yoji Nagashima, Takeshi Sasaki, Noboru Nakaigawa, Hisashi Hasumi, Shingo Kato, and Yoshinobu Kubota
Mol Cancer Ther 2005 4: 1699-1709 doi: 10.1158/1535-7163.MCT-04-0295 [Abstract] [Full Text] [PDF]  

Gene therapy with E2F-1 up-regulates the protein kinase PKR and inhibits growth of leiomyosarcoma in vivo

Stephan A. Vorburger, Nophadol Hetrakul, Weiya Xia, Marcia Wilson-Heiner, Nadeem Mirza, Raphael E. Pollock, Barry Feig, Stephen G. Swisher, and Kelly K. Hunt
Mol Cancer Ther 2005 4: 1710-1716 doi: 10.1158/1535-7163.MCT-05-0036 [Abstract] [Full Text] [PDF]  

Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion

Alexandre Kaliski, Laurence Maggiorella, Keith A. Cengel, Denis Mathe, Valerie Rouffiac, Paule Opolon, Nathalie Lassau, Jean Bourhis, and Eric Deutsch
Mol Cancer Ther 2005 4: 1717-1728 doi: 10.1158/1535-7163.MCT-05-0179 [Abstract] [Full Text] [PDF]  

Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and in vitro and in vivo biological activity

Ingrid M. Fellows, Michael Schwaebe, Thomas S. Dexheimer, Hariprasad Vankayalapati, Mary Gleason-Guzman, Jeffrey P. Whitten, and Laurence H. Hurley
Mol Cancer Ther 2005 4: 1729-1739 doi: 10.1158/1535-7163.MCT-05-0183 [Abstract] [Full Text] [PDF]  

The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells

Linda C. Hsi, Xiaopei Xi, Yuanqing Wu, and Scott M. Lippman
Mol Cancer Ther 2005 4: 1740-1746 doi: 10.1158/1535-7163.MCT-05-0218 [Abstract] [Full Text] [PDF]  

Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak

Shivendra V. Singh, Yan Zeng, Dong Xiao, Victor G. Vogel, Joel B. Nelson, Rajiv Dhir, and Yamini B. Tripathi
Mol Cancer Ther 2005 4: 1747-1754 doi: 10.1158/1535-7163.MCT-05-0223 [Abstract] [Full Text] [PDF]  

Role of O⁶-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine

Kimiko Ishiguro, Krishnamurthy Shyam, Philip G. Penketh, and Alan C. Sartorelli
Mol Cancer Ther 2005 4: 1755-1763 doi: 10.1158/1535-7163.MCT-05-0169 [Abstract] [Full Text] [PDF]  

Inhibition of phosphatidylinositol 3-kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment

Suzanne D. Westfall and Michael K. Skinner
Mol Cancer Ther 2005 4: 1764-1771 doi: 10.1158/1535-7163.MCT-05-0192 [Abstract] [Full Text] [PDF]  

Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells

Roberto R. Rosato, Jorge A. Almenara, Sonia C. Maggio, Peter Atadja, Ruth Craig, Julie Vrana, Paul Dent, and Steven Grant
Mol Cancer Ther 2005 4: 1772-1785 doi: 10.1158/1535-7163.MCT-05-0157 [Abstract] [Full Text] [PDF]  

Subsieve-size agarose capsules enclosing ifosfamide-activating cells: a strategy toward chemotherapeutic targeting to tumors

Shinji Sakai, Kenji Kawabata, Shinji Tanaka, Norifumi Harimoto, Ichiro Hashimoto, Changjun Mu, Brian Salmons, Hiroyuki Ijima, and Koei Kawakami
Mol Cancer Ther 2005 4: 1786-1790 doi: 10.1158/1535-7163.MCT-05-0227 [Abstract] [Full Text] [PDF]  

A ß-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy

Fiona A. Harding, Amy D. Liu, Marcia Stickler, O. Jennifer Razo, Regina Chin, Nargol Faravashi, Wendy Viola, Tom Graycar, V. Pete Yeung, Wolfgang Aehle, Daan Meijer, Stephanie Wong, M. Harunur Rashid, Ana M. Valdes, and Volker Schellenberger
Mol Cancer Ther 2005 4: 1791-1800 doi: 10.1158/1535-7163.MCT-05-0189 [Abstract] [Full Text] [PDF]  

Human single-domain neutralizing intrabodies directed against Etk kinase: a novel approach to impair cellular transformation

Keren Paz, Laura A. Brennan, Michelle Iacolina, Jacqueline Doody, Yaron R. Hadari, and Zhenping Zhu
Mol Cancer Ther 2005 4: 1801-1809 doi: 10.1158/1535-7163.MCT-05-0174 [Abstract] [Full Text] [PDF]  

Meeting Report:

Clinical translation of epigenetics in cancer: eN-CORe—a report on the second workshop

Arthur Zelent, Kevin Petrie, Reuben Lotan, Samuel Waxman, and Steven D. Gore
Mol Cancer Ther 2005 4: 1810-1819 doi: 10.1158/1535-7163.MCT-05-0230 [Abstract] [Full Text] [PDF]  

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