On The Cover

Met kinase homology model (top panel). A homology model of the Met kinase was developed based on the crystal structures of the FGFR1 receptor kinase. ATP was docked into the active site based on the co-crystal of FGFR1 with ATP. Amino acids within 6 Angstroms of ATP that differ between Met and FGFR1 are highlighted in yellow. Lower panel shows the Met kinase homology model with a synthetic Met inhibitor, SU11271, docked in ATP binding site. For details, see Wang et al. in this issue.