APTO-253 is a new addition to the repertoire of drugs that can exploit DNA BRCA1/2 deficiency

Supplementary Data

• Supplementary Material - Chemical Synthesis of APTO-253
• Figure S1 - Influx and efflux of APTO-253 and Fe(253)3.
• Figure S2 - The accumulation of phospho-ATM, γ-H2AFX and cleaved PARP in Raji compared to that in Raji/253R cells exposed to APTO-253 for 24 h.
• Figure S3 - Role of ABCG2 in resistance to Fe(253)3.
• Table S1 - Rate of efflux of APTO-253 and Fe(253)3 from Raji and Raji/253R cells over first 2 hours (log fmole/10^7 cells/h)
• Table S2 - Rank order of genes up-regulated in Raji/253R cells.
• Table S3 - ABC transporter family member genes up-regulated in Raji/253R cells