ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms

Kasey L. Couts; Judson Bemis; Jacqueline A. Turner; Stacey M. Bagby; Danielle Murphy; Jason Christiansen; Jennifer D. Hintzsche; Anh Le; Todd M. Pitts; Keith Wells; Allison Applegate; Carol Amato; Pratik Multani; Edna Chow-Maneval; John J. Tentler; Yiqun G. Shellman; Matthew J. Rioth; Aik-Choon Tan; Rene Gonzalez; Theresa Medina; Robert C. Doebele; William A. Robinson

doi:10.1158/1535-7163.MCT-17-0472

Cancer Biology and Translational Studies

ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms

Kasey L. Couts, Judson Bemis, Jacqueline A. Turner, Stacey M. Bagby, Danielle Murphy, Jason Christiansen, Jennifer D. Hintzsche, Anh Le, Todd M. Pitts, Keith Wells, Allison Applegate, Carol Amato, Pratik Multani, Edna Chow-Maneval, John J. Tentler, Yiqun G. Shellman, Matthew J. Rioth, Aik-Choon Tan, Rene Gonzalez, Theresa Medina, Robert C. Doebele and William A. Robinson

Kasey L. Couts

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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For correspondence: kasey.couts@ucdenver.edu

Judson Bemis

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Jacqueline A. Turner

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Stacey M. Bagby

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Danielle Murphy

Ignyta, Inc, San Diego, California.

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Jason Christiansen

Ignyta, Inc, San Diego, California.

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Jennifer D. Hintzsche

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Anh Le

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Todd M. Pitts

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Keith Wells

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Allison Applegate

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Carol Amato

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Pratik Multani

Ignyta, Inc, San Diego, California.

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Edna Chow-Maneval

Ignyta, Inc, San Diego, California.

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John J. Tentler

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Yiqun G. Shellman

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Matthew J. Rioth

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Aik-Choon Tan

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Rene Gonzalez

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Theresa Medina

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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Robert C. Doebele

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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William A. Robinson

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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DOI: 10.1158/1535-7163.MCT-17-0472 Published January 2018

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January 2018
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ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms

Mol Cancer Ther January 1 2018 (17) (1) 222-231; DOI: 10.1158/1535-7163.MCT-17-0472

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ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms

Mol Cancer Ther January 1 2018 (17) (1) 222-231; DOI: 10.1158/1535-7163.MCT-17-0472

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