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Molecular Cancer Therapeutics
Molecular Cancer Therapeutics

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Chemical Therapeutics

VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer

Stefan Hart, Veronica Novotny-Diermayr, Kee Chuan Goh, Meredith Williams, Yong Cheng Tan, Lai Chun Ong, Albert Cheong, Bee Kheng Ng, Chithra Amalini, Babita Madan, Harish Nagaraj, Ramesh Jayaraman, Khalid M. Pasha, Kantharaj Ethirajulu, Wee Joo Chng, Nurulhuda Mustafa, Boon Cher Goh, Cyril Benes, Ultan McDermott, Mathew Garnett, Brian Dymock and Jeanette M. Wood
Stefan Hart
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Veronica Novotny-Diermayr
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Kee Chuan Goh
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Meredith Williams
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Yong Cheng Tan
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Lai Chun Ong
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Albert Cheong
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Bee Kheng Ng
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Chithra Amalini
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Babita Madan
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Harish Nagaraj
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Ramesh Jayaraman
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Khalid M. Pasha
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Kantharaj Ethirajulu
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Wee Joo Chng
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United KingdomAuthors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Nurulhuda Mustafa
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Boon Cher Goh
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Cyril Benes
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Ultan McDermott
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Mathew Garnett
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Brian Dymock
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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Jeanette M. Wood
Authors' Affiliations: S*BIO Pte Ltd.; Cancer Science Institute of Singapore, National University of Singapore; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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DOI: 10.1158/1535-7163.MCT-12-0466 Published February 2013
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Article Information

Volume 12, Issue 2, pp. 151-161

DOI 
https://doi.org/10.1158/1535-7163.MCT-12-0466
PubMed 
23270925

Published By 
American Association for Cancer Research
Print ISSN 
1535-7163
Online ISSN 
1538-8514
History 
  • Received May 14, 2012
  • Revision received December 13, 2012
  • Accepted December 17, 2012
  • Published first December 27, 2012.

Article Versions

  • Previous version (December 27, 2012 - 14:39).
  • Previous version (January 31, 2013 - 14:04).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2012 American Association for Cancer Research.

Author Information

  1. Stefan Hart1,
  2. Veronica Novotny-Diermayr1,
  3. Kee Chuan Goh1,
  4. Meredith Williams1,
  5. Yong Cheng Tan1,
  6. Lai Chun Ong1,
  7. Albert Cheong1,
  8. Bee Kheng Ng1,
  9. Chithra Amalini1,
  10. Babita Madan1,
  11. Harish Nagaraj1,
  12. Ramesh Jayaraman1,
  13. Khalid M. Pasha1,
  14. Kantharaj Ethirajulu1,
  15. Wee Joo Chng2,3,
  16. Nurulhuda Mustafa2,
  17. Boon Cher Goh2,
  18. Cyril Benes4,
  19. Ultan McDermott5,
  20. Mathew Garnett5,
  21. Brian Dymock1, and
  22. Jeanette M. Wood1
  1. Authors' Affiliations: 1S*BIO Pte Ltd.; 2Cancer Science Institute of Singapore, National University of Singapore; 3Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore; 4Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts; and 5Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
  1. Corresponding Author:
    Stefan Hart, S*BIO Pte Ltd., 1 Science Park Road, #05-09 The Capricorn, Singapore 117528, Singapore. Phone: 65-6645-3412; Fax: 65-6225-4654; E-mail: stefan.sbio{at}gmail.com
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Molecular Cancer Therapeutics: 12 (2)
February 2013
Volume 12, Issue 2
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VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer
Stefan Hart, Veronica Novotny-Diermayr, Kee Chuan Goh, Meredith Williams, Yong Cheng Tan, Lai Chun Ong, Albert Cheong, Bee Kheng Ng, Chithra Amalini, Babita Madan, Harish Nagaraj, Ramesh Jayaraman, Khalid M. Pasha, Kantharaj Ethirajulu, Wee Joo Chng, Nurulhuda Mustafa, Boon Cher Goh, Cyril Benes, Ultan McDermott, Mathew Garnett, Brian Dymock and Jeanette M. Wood
Mol Cancer Ther February 1 2013 (12) (2) 151-161; DOI: 10.1158/1535-7163.MCT-12-0466

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VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer
Stefan Hart, Veronica Novotny-Diermayr, Kee Chuan Goh, Meredith Williams, Yong Cheng Tan, Lai Chun Ong, Albert Cheong, Bee Kheng Ng, Chithra Amalini, Babita Madan, Harish Nagaraj, Ramesh Jayaraman, Khalid M. Pasha, Kantharaj Ethirajulu, Wee Joo Chng, Nurulhuda Mustafa, Boon Cher Goh, Cyril Benes, Ultan McDermott, Mathew Garnett, Brian Dymock and Jeanette M. Wood
Mol Cancer Ther February 1 2013 (12) (2) 151-161; DOI: 10.1158/1535-7163.MCT-12-0466
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