This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lockhart, A. C. Articles by Kim, R. B. Search for Related Content PubMed PubMed Citation Articles by Lockhart, A. C. Articles by Kim, R. B. Related Collections Clinical Research Clinical Research: Clinical Pharmacology

Review

Pharmacogenetics of ATP-binding Cassette Transporters in Cancer and Chemotherapy¹

Departments of Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232

² To whom requests for reprints should be addressed, at 572 RRB, 23rd Avenue at Pierce Avenue, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-6602. Phone: (615) 343-1522; Fax: (615) 343-7605; E-mail: richard.kim{at}vanderbilt.edu

The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.

This article has been cited by other articles:

				A. R. Erdman, L. M. Mangravite, T. J. Urban, L. L. Lagpacan, R. A. Castro, M. de la Cruz, W. Chan, C. C. Huang, S. J. Johns, M. Kawamoto, et al. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics Am J Physiol Renal Physiol, April 1, 2006; 290(4): F905 - F912. [Abstract] [Full Text] [PDF]

				W. L. Perry III, R. L. Shepard, J. Sampath, B. Yaden, W. W. Chin, P. W. Iversen, S. Jin, A. Lesoon, K. A. O'Brien, V. L. Peek, et al. Human Splicing Factor SPF45 (RBM17) Confers Broad Multidrug Resistance to Anticancer Drugs When Overexpressed-- a Phenotype Partially Reversed By Selective Estrogen Receptor Modulators Cancer Res., August 1, 2005; 65(15): 6593 - 6600. [Abstract] [Full Text] [PDF]

				W. J. Huss, D. R. Gray, N. M. Greenberg, J. L. Mohler, and G. J. Smith Breast Cancer Resistance Protein-Mediated Efflux of Androgen in Putative Benign and Malignant Prostate Stem Cells Cancer Res., August 1, 2005; 65(15): 6640 - 6650. [Abstract] [Full Text] [PDF]