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Laboratorio di Genomica Funzionale, Sezione di Istologia ed Embriologia, Dipartimento di Morfologia ed Embriologia, Università degli Studi di Ferrara, 44100 Ferrara [F. F., L. S., F. P., R. E., S. V.]; Clinica ORL, Ferrara [F. C., A. Pa., S. P.]; Istituto di Istologia ed Embriologia, 40100 Bologna [L. T., P. C.]; Department of Bioinformatics, 4NET, 44100 Ferrara [E. P.]; Clinica ORL, Università di Chieti 66100 [A. Pi.]; Istituto di Anatomia Patologica, Università di Ancona 60100 [C. R., M. F.]; Centro di Genetica Molecolare "Fondazione Carisbo," Università degli Studi di Bologna, Bologna [L. T., P. C.]; and Telethon Institute of Genetics and Medicine, 80131 Napoli [S. V.], Italy

Differentially expressed genes among different benign and malignant salivary gland tumors were identified by use of cDNA microarrays containing 19,000 human expressed sequence tags. Tumors were classified by using a subset of 486 genes. Benign Warthin’s tumor and pleomorphic adenoma showed very distinctive gene expression patterns. One hundred and thirty-three genes differentiated the single malignant clear cell carcinoma from non-tumor salivary glands (P < 0.01), whereas only 16 genes separated it from the highly related benign pleomorphic adenoma (P < 0.01). Fifty-seven cDNAs were associated with mucoepidermoid carcinoma (P < 0.01). The identified genes might help to disclose the molecular mechanisms and processes underlying malignant salivary gland tumors.

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